AbPlus™ Anti-TNFRSF18 Magnetic Beads (VS-0424-XY257)

Name: AbPlus™ Anti-TNFRSF18 Magnetic Beads (VS-0424-XY257)
SKU: VS-0424-XY257
Rating: 5 (1 reviews)

CAT#: VS-0424-XY257

The AbPlus Anti-TNFRSF18 Magnetic Beads (VS-0424-XY257) is an innovative affinity resin which is bound with anti-TNFRSF18 specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of TNFRSF18 protein under native and denaturing conditions.

Gene Expression

Normal Tissue Figure 1 IHC staining of human spleen

Immunohistochemical staining of human spleen shows moderate cytoplasmic positivity in red pulp and cells in white pulp.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/ihc_selected.jpg

Normal Tissue Figure 2 Cerebral cortex

Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_B_9_5.jpg

Normal Tissue Figure 3 Colon

Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_7_3.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_7_5.jpg

Normal Tissue Figure 5 Testis

Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_5_6.jpg

Normal Tissue Figure 6 Bone marrow

Hematopoietic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_B_4_4.jpg

Normal Tissue Figure 7 Lymph node

Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_8_8.jpg

RNA Expression Figure 8 RNA cell line category: Group enriched (RPMI-8226, SCLC-21H)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186891-TNFRSF18

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Specifications

Applications
Immunoprecipitation, Protein Purification

Matrix
Magrose bead (> 50 μmol/mL gel)

Bead Ligand
Anti-TNFRSF18 specific antibody

Target
TNFRSF18

Immunogen
Human AITR-GST fusion protein

Target Species
Human

Bead Capacity
20-30 mg/mL binding antibody

Bead size
10-37 μm

Stability
pH 2-14

Format
20% Suspension

Buffer
PBS, pH 7.4, with 1% BSA

Preservative
0.03% Proclin 300

Storage
Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.

Applications

Application Notes
The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.

Target

Introduction
This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Alternative Names
TNFRSF18; tumor necrosis factor receptor superfamily, member 18; AITR; GITR; CD357; GITR-D; tumor necrosis factor receptor superfamily member 18; activation-inducible TNFR family receptor; glucocorticoid-induced TNFR-related protein; TNF receptor superfamily activation-inducible protein

Gene ID
8784

UniProt ID
Q9Y5U5

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Downloadable Resources

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Datasheet

Datasheet - VS-0424-XY257.pdf

MSDS

MSDS - VS-0424-XY257.pdf

COA

Certificate of Analysis Lookup

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