Recombinant Anti-TNFRSF18 Vesicular Antibody, EV Displayed (VS-0425-YC273) (CAT#: VS-0425-YC273)

• Application
• ELISA, FC, Cell-uptake

• Product Type
• Ab-Fc-EVs

• Antibody Quantification (Ab/EV)
• ~100 Ab/EV

• Target
• TNFRSF18

• Host Animal
• Mouse

• Antibody Isotype
• IgG

• Species Reactivity
• Human, Cynomolgus

• Expression Cell
• Mammalian cell

• EV-sorting domain
• CD63

• Fc-binding domain
• Protein A

• EV Size
• 30~150 nm

• Producing Cell
• HEK293F

• Isolation Method
• Gradient centrifugation

• Purification
• qEV size exclusion chromatography

• Concentration
• 1 x 10¹⁰

• Size
• 1 mL

• Buffer
• PBS

• Storage
• Store at -80°C for 12 months

• Full Name
• TNF receptor superfamily member 18

• Biological Process
• Apoptosis

• Molecular Function
• Receptor

• Introduction
• This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

• Alternative Names
• AITR, CD357, GITR

• Gene ID
• 8784

• UniProt ID
• Q9Y5U5

Select a product category from the dropdown menu below to view related products.