Rat Anti-Tnfrsf18 Agonistic Antibody (clone DTA-1)

Name: Rat Anti-Tnfrsf18 Agonistic Antibody (clone DTA-1)
SKU: VS-0724-XY47
Rating: 5 (1 reviews)

CAT#: VS-0724-XY47

This antibody was raised by immunising Wistar rats with the CD25+CD4+ T cell line. This DTA-1 clone secreted a monoclonal rat immunoglobulin G2a (IgG2a) that showed high neutralizing activity. It recognizes and binds to mouse Tnfrsf18. It has been determined using Western Blot, Flow cytometry, Immunoprecipitation and Agonistic assays.

Gene Expression

Normal Tissue Figure 1 IHC staining of human spleen

Immunohistochemical staining of human spleen shows moderate cytoplasmic positivity in red pulp and cells in white pulp.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/ihc_selected.jpg

Normal Tissue Figure 2 Cerebral cortex

Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_B_9_5.jpg

Normal Tissue Figure 3 Colon

Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_7_3.jpg

Normal Tissue Figure 4 Kidney

Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_7_5.jpg

Normal Tissue Figure 5 Testis

Leydig cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_5_6.jpg

Normal Tissue Figure 6 Bone marrow

Hematopoietic cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_B_4_4.jpg

Normal Tissue Figure 7 Lymph node

Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/8025/24709_A_8_8.jpg

RNA Expression Figure 8 RNA cell line category: Group enriched (RPMI-8226, SCLC-21H)

Cell lines ordered by descending RNA expression order.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186891-TNFRSF18

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Specifications

Host Species
Rat

Type
Rat IgG2a, lambda

Specificity
Tnfrsf18

Species Reactivity
Mouse

Clone
DTA-1

Applications
FC, WB, IP, Agonistic assays

Product Property

Purification
Protein G purified

Purity
>95%, determined by SDS-PAGE

Format
Liquid

Buffer
PBS

Preservative
0.02 % Proclin 300

Storage
Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Target

Alternative Names
AITR; Gitr

Gene ID
21936

UniProt ID
O35714

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Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - VS-0724-XY47.pdf

MSDS

MSDS - VS-0724-XY47.pdf

COA

Certificate of Analysis Lookup

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