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    Human Anti-TNFSF10 Recombinant Antibody (clone DR4-4) (CAT#: VS-0423-CJ41)

    This Human anti-TNFSF10 antibody (clone DR4-4) is a product that recognizes Human recombinant DR4.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
    Quantity :
    Conjugation :
    Fc Engineering :
    Modalities :
    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IHC staining of human kidney
    Figure 1 IHC staining of human kidney
    (Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in cells in tubules.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/54938/ihc_selected.jpg
    Normal Tissue
    Figure 2 Cerebral cortex
    Figure 2 Cerebral cortex
    (Glial cells
    Staining: Low
    Intensity: Moderate
    Quantity: <25%
    Location: Cytoplasmic/membranous
    Neuronal cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous nuclear
    Neuropil
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/54938/134466_B_8_5.jpg
    Figure 3 Colon
    Figure 3 Colon
    (Endothelial cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Glandular cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Peripheral nerve/ganglion
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/54938/134466_A_9_3.jpg
    Figure 4 Kidney
    Figure 4 Kidney
    (Cells in glomeruli
    Staining: Medium
    Intensity: Strong
    Quantity: <25%
    Location: Cytoplasmic/membranous
    Cells in tubules
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/54938/134466_A_7_5.jpg
    Figure 5 Testis
    Figure 5 Testis
    (Cells in seminiferous ducts
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear
    Leydig cells
    Staining: Low
    Intensity: Weak
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/54938/134466_A_4_6.jpg
    Figure 6 Lymph node
    Figure 6 Lymph node
    (Germinal center cells
    Staining: Low
    Intensity: Weak
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/54938/134466_A_7_8.jpg
    RNA Expression
    Figure 7 RNA cell line category: Cell line enhanced (BEWO, CAPAN-2, HaCaT, HMC-1, RPTEC TERT1)
    Figure 7 RNA cell line category: Cell line enhanced (BEWO, CAPAN-2, HaCaT, HMC-1, RPTEC TERT1)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000121858-TNFSF10/subcellular

    Specifications

    • Host Species
    • Human
    • Type
    • Human IgG
    • Specificity
    • Human TNFSF10
    • Species Reactivity
    • Human
    • Clone
    • DR4-4
    • Applications
    • IB, IA, FC
    • Conjugate
    • Unconjugated
    • Related Disease
    • Tumors

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Buffer
    • PBS
    • Storage
    • Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

    Applications

    • Application Notes
    • This antibody has been reported for use in Immunoblotting, Immunoassay, Flow Cytometry.

    Target

    • Alternative Names
    • TL2; APO2L; CD253; TANCR; TRAIL; Apo-2L; TNLG6A
    • Sequence Similarities
    • Belongs to the tumor necrosis factor family.
    • Cellular Localization
    • Cell membrane, Membrane, Secreted
    • Post Translation Modifications
    • Tyrosine phosphorylated by PKDCC/VLK.
    • Function
    • Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288).
      Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.

    Recommended Products

    Isotype Control

    Secondary Antibody

    Recommended Dilution Buffer

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "Clone DR4-4"

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    CAT Product Name Application Type
    MOB-987 Recombinant Anti-human TNFSF10 Antibody ELISA, WB, FC, FuncS IgG
    MHH-987 Recombinant Human Anti-human TNFSF10 Antibody ELISA, WB, FC, FuncS IgG
    MOB-0837MZ Recombinant Mouse Anti-Human TNFSF10 Antibody (clone C-T34) FC Mouse antibody
    HPAB-1451-FY Human Anti-TNFSF10 Recombinant Antibody (HPAB-1451-FY) Activ Humanized IgG
    VS3-FY1468 Recombinant Mouse Anti-TNFSF10 Antibody (clone 6D4C6) ELISA, FC Mouse IgG1

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