Recombinant Anti-TNFSF15 Eliminating Antibody, pH-Sensitive (TAN2-2 var.)
CAT#: VS-0625-YC318
The anti-TNFSF15 eliminating antibody is an engineered pH-sensitive antibody against mouse TNFSF15. TNFSF15, an endothelial cytokine, inhibits proliferation and functions in angiogenesis inhibition. The antibody has a novel TNFSF15-sweeping activity in vivo, which selectively eliminatesthe soluble TNFSF15 from plasma. Compared to conventional antibody, the mAb exerted in vivo efficacy by simultaneously engineering both pH-dependent antigen binding, to mimic the pH-dependent receptor-ligand binding of such endocytic receptors, and increased FcRn binding affinity at neutral pH, to mimic the cell-bound form of the receptors.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line RT4
Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm & nuclear membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46522/1383_A7_2_selected.jpg
Normal Tissue
Figure 2 IHC staining of human esophagus
Immunohistochemical staining of human esophagus shows strong membranous positivity in squamous epithelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12948/29318_B_4_1_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12948/29318_B_9_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12948/29318_A_8_3.jpg
Normal Tissue
Figure 5 Kidney
Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12948/29318_A_8_5.jpg
Normal Tissue
Figure 6 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12948/29318_A_6_6.jpg
Normal Tissue
Figure 7 Skin
Epidermal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12948/29318_B_5_8.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/12948/29318_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced.
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000181634-TNFSF15
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Specifications
- Immunogen
- Recombinant mouse TL1A (aa 77-252) with Fc tag
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Mouse TNFSF15
- Species Reactivity
- Mouse
- Clone
- TAN2-2 var.
- Applications
- Antigen-Sweeping In Vivo.
Product Property
- Purification
- Protein A/G purified
- Purity
- >95%
- Format
- Liquid
- Buffer
- PBS only
- Preservative
- None
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "TNFSF15"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-334CQ | Mouse Anti-TNFSF15 Recombinant Antibody (TAB-334CQ) | ELISA | Mouse IgG2a, κ |
| TAB-335CQ | Mouse Anti-TNFSF15 Recombinant Antibody (TAB-335CQ) | ELISA, FC, BL | Mouse IgG2a, κ |
| TAB-338CQ | Hamster Anti-TNFSF15 Recombinant Antibody (TAB-338CQ) | ELISA, FC, Block | Hamster IgG |
| TAB-339CQ | Hamster Anti-TNFSF15 Recombinant Antibody (TAB-339CQ) | ELISA, FC, BL | Hamster IgG |
| TAB-346CQ | Mouse Anti-TNFSF15 Recombinant Antibody (TAB-346CQ) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-340CQ | Human Anti-TNFSF15 Recombinant Antibody (TAB-340CQ) | ELISA, FC, Neut | Human IgG1, κ |
| TAB-341CQ | Human Anti-TNFSF15 Recombinant Antibody (TAB-341CQ) | ELISA, FC, Inhib | Human IgG1, κ |
| TAB-342CQ | Human Anti-TNFSF15 Recombinant Antibody (TAB-342CQ) | ELISA, FC, Neut | Human IgG1, κ |
| TAB-343CQ | Human Anti-TNFSF15 Recombinant Antibody (TAB-343CQ) | ELISA | Human IgG1, κ |
| TAB-344CQ | Human Anti-TNFSF15 Recombinant Antibody (TAB-344CQ) | ELISA, FC, Neut | Human IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-351CQ | Human Anti-TNFSF15 Recombinant Antibody (TAB-351CQ) | FC, ELISA | Humanized antibody |
| TAB-352CQ | Human Anti-TNFSF15 Recombinant Antibody (TAB-352CQ) | Inhib | Humanized antibody |
| TAB-336CQ-F(E) | Human Anti-TNFSF15 Recombinant Antibody; Fab Fragment (TAB-336CQ-F(E)) | ELISA, FC, BL | Humanized Fab |
| TAB-337CQ-F(E) | Human Anti-TNFSF15 Recombinant Antibody; Fab Fragment (TAB-337CQ-F(E)) | ELISA, FC, BL | Humanized Fab |
| TAB-347CQ-F(E) | Human Anti-TNFSF15 Recombinant Antibody; Fab Fragment (TAB-347CQ-F(E)) | ELISA, FC, BL | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-2187CQ | Rat Anti-Tnfsf15 Recombinant Antibody (clone CBL658) | Neut | Rat IgG1 |
| NEUT-2188CQ | Rat Anti-Tnfsf15 Recombinant Antibody (clone CBL204) | WB, Neut | Rat IgG1 |
| NEUT-2189CQ | Rabbit Anti-TNFSF15 Recombinant Antibody (NEUT-2189CQ) | Neut, WB, IHC | Rabbit IgG |
| NEUT-2190CQ | Rat Anti-TNFSF15 Recombinant Antibody (clone CBL610) | WB, Neut | Rat IgG1 |
| NEUT-2191CQ | Rabbit Anti-TNFSF15 Recombinant Antibody (clone CBL722) | WB, Neut | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0011-WJ-F(E) | Human Anti-TNFSF15 Recombinant Antibody; Fab Fragment (HPAB-0011-WJ-F(E)) | ELISA, Neut | Human Fab |
| HPAB-0831-FY-S(P) | Mouse Anti-TNFSF15 Recombinant Antibody (HPAB-0831-FY-S(P)); scFv Fragment | Inhib, ELISA | Mouse scFv |
| HPAB-0455-WJ-F(E) | Human Anti-TNFSF15 Recombinant Antibody; Fab Fragment (HPAB-0455-WJ-F(E)) | ELISA | Humanized Fab |
| HPAB-0456-WJ-F(E) | Human Anti-TNFSF15 Recombinant Antibody; Fab Fragment (HPAB-0456-WJ-F(E)) | ELISA | Humanized Fab |
| HPAB-0457-WJ-F(E) | Human Anti-TNFSF15 Recombinant Antibody; Fab Fragment (HPAB-0457-WJ-F(E)) | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-N0287-YC | Mouse Anti-TNFSF15 Recombinant Antibody (HPAB-N0287-YC) | Inhib, Neut | Mouse IgG |
| HPAB-N0288-YC | Mouse Anti-TNFSF15 Recombinant Antibody (HPAB-N0288-YC) | Inhib, Neut | Mouse IgG |
| HPAB-N0289-YC | Human Anti-TNFSF15 Recombinant Antibody (HPAB-N0289-YC) | Inhib, Neut | Humanized IgG |
| HPAB-N0290-YC | Human Anti-TNFSF15 Recombinant Antibody (HPAB-N0290-YC) | Block | Human IgG |
| HPAB-N0291-YC | Mouse Anti-TNFSF15 Recombinant Antibody (HPAB-N0291-YC) | ELISA, Neut, Inhib | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0831-FY-F(E) | Mouse Anti-TNFSF15 Recombinant Antibody (HPAB-0831-FY-F(E)); Fab Fragment | Inhib, ELISA | Mouse Fab |
| HPAB-0832-FY-F(E) | Mouse Anti-TNFSF15 Recombinant Antibody (HPAB-0832-FY-F(E)); Fab Fragment | Inhib, ELISA | Mouse Fab |
| HPAB-0833-FY-F(E) | Mouse Anti-TNFSF15 Recombinant Antibody (HPAB-0833-FY-F(E)); Fab Fragment | Inhib, ELISA | Mouse Fab |
| HPAB-0834-FY-F(E) | Mouse Anti-TNFSF15 Recombinant Antibody (HPAB-0834-FY-F(E)); Fab Fragment | Inhib, ELISA | Mouse Fab |
| HPAB-0835-FY-F(E) | Mouse Anti-TNFSF15 Recombinant Antibody (HPAB-0835-FY-F(E)); Fab Fragment | Inhib, ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7395 | Anti-TNFSF15 Immunohistochemistry Kit | IHC |
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