Mouse Anti-TP63 Recombinant Antibody (clone 14D5E8F12) (CAT#: VS11-QX140)
This product is a recombinant mouse antibody that recognizes the p40 peptide of the human TP63. This antibody can be used for the following applications: ELISA, IHC. P63 is a member of the p53 gene family, which plays an important role in the development, differentiation, and morphogenesis of various epithelial tissues, is of great significance for the development of the ectoderm during embryogenesis.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line RT4
(Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6289/1843_E1_9_cr5af96f44b42f8_selected.jpg
(Immunofluorescent staining of human cell line RT4 shows localization to nucleoplasm.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6289/1843_E1_9_cr5af96f44b42f8_selected.jpg
Figure 2 Skin 1
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6288/19019_B_7_1_val_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/6288/19019_B_7_1_val_selected.jpg
Figure 3 Skin
(Cells in basal layer Staining: High Intensity: Strong Quantity:>75% Cells in granular layer Staining: Low Intensity: Moderate Quantity: <25% Cells in spinous layer Staining: High Intensity: Strong Quantity: 75%-25% Eccrine glands Staining: High Intensity: Strong Quantity: 75%-25% Hair follicles Staining: High Intensity: Strong Quantity: 75%-25% Sebaceous glands Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/83/860_B_9_1.jpg
(Cells in basal layer Staining: High Intensity: Strong Quantity:>75% Cells in granular layer Staining: Low Intensity: Moderate Quantity: <25% Cells in spinous layer Staining: High Intensity: Strong Quantity: 75%-25% Eccrine glands Staining: High Intensity: Strong Quantity: 75%-25% Hair follicles Staining: High Intensity: Strong Quantity: 75%-25% Sebaceous glands Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/83/860_B_9_1.jpg
Figure 4 Lymph node
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Non-germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/83/860_A_7_8.jpg
(Germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Nuclear Non-germinal center cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Nuclear)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/83/860_A_7_8.jpg
Figure 5 Testis
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/83/860_A_6_6.jpg
(Elongated or late spermatids Staining: Medium Intensity: Moderate Quantity:>75%)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/83/860_A_6_6.jpg
Figure 6 RNA cell line category: Group enriched (HaCaT, HBEC3-KT, hTCEpi, hTERT-HME1, RT4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000073282-TP63
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000073282-TP63
Specifications
- Immunogen
- The p40 peptide comprising amino acids 4-19 (LENNAQTQFSEPQYTN) of the p63 protein
- Host Species
- Mouse
- Derivation
- Mouse
- Type
- Mouse IgG1, κ
- Specificity
- Human TP63
- Species Reactivity
- Human
- Clone
- 14D5E8F12
- Applications
- ELISA, IHC
- Conjugate
- Unconjugated
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- 1 mg/mL (Please refer to the vial label for the specific concentration.)
- Buffer
- 0.2 μm filtered solution in PBS
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Shipped at 4°C.
Target
- Alternative Names
- AIS; KET; LMS; NBP; RHS; p40; p51; p63; EEC3; OFC8; p73H; p73L; SHFM4; TP53L; TP73L; p53CP; TP53CP; B(p51A); B(p51B); tumor protein 63; amplified in squamous cell carcinoma; chronic ulcerative stomatitis protein; keratinocyte transcription factor KET; transformation-related protein 63; tumor protein p53-competing protein
- Gene ID
- 8626
- UniProt ID
- Q9H3D4
- Long Name
- Tumor protein 63
- Sequence Similarities
- Belongs to the p53 family.
- Cellular Localization
- Nucleoplasm
- Function
- Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3647 | Rabbit Anti-TP63 Recombinant Antibody (clone DS3647AB) | ICC, IF, IP, WB | Rabbit IgG |
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