AbPlus™ Anti-TTR Magnetic Beads (AD7F6)
CAT#: VS-0424-XY265
The AbPlus Anti-TTR Magnetic Beads (AD7F6) is an innovative affinity resin which is bound with anti-TTR specific antibody (AD7F6). The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of TTR protein under native and denaturing conditions.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line CACO-2
Immunofluorescent staining of human cell line CACO-2 shows localization to the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/1030_B12_3_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human hippocampus
Immunohistochemical staining of human hippocampus shows plasma positivity in blood vessels.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/ih_additional_tissue/2550/1625_959_400x400.jpg
Subcellular Location and Protein Expression
Figure 3 IHC staining of human liver
Immunohistochemical staining of human liver shows moderate cytoplasmic positivity in hepatocytes.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 4 IHC staining of human pancreas
Immunohistochemical staining of human pancreas shows selective positivity in islets of Langerhans.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/62567/ihc_selected.jpg
Subcellular Location and Protein Expression
Figure 5 IHC staining of human kidney
Immunohistochemical staining of human kidney shows strong granular cytoplasmic positivity in cells in tubules.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/ihc_selected.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2517/6846_A_9_4.jpg
Normal Tissue
Figure 7 Pancreas
Pancreatic endocrine cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2550/141382_A_3_3.jpg
Normal Tissue
Figure 8 Kidney
Cells in tubules
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/73406/153523_A_7_5.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (CACO-2, EFO-21, Hep G2, U-2 OS)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118271-TTR
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magrose bead (> 50 μmol/mL gel)
- Bead Ligand
- Anti-TTR specific antibody (AD7F6)
- Target
- TTR
- Immunogen
- Recombinant mutant TTR (Y78F)
- Target Species
- Human
- Antibody Clone
- AD7F6
- Bead Capacity
- 20-30 mg/mL binding antibody
- Bead size
- 10-37 μm
- Stability
- pH 2-14
- Format
- 20% Suspension
- Buffer
- PBS, pH 7.4, with 1% BSA
- Preservative
- 0.03% Proclin 300
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- This gene encodes one of the three prealbumins, which include alpha-1-antitrypsin, transthyretin and orosomucoid. The encoded protein, transthyretin, is a homo-tetrameric carrier protein, which transports thyroid hormones in the plasma and cerebrospinal fluid. It is also involved in the transport of retinol (vitamin A) in the plasma by associating with retinol-binding protein. The protein may also be involved in other intracellular processes including proteolysis, nerve regeneration, autophagy and glucose homeostasis. Mutations in this gene are associated with amyloid deposition, predominantly affecting peripheral nerves or the heart, while a small percentage of the gene mutations are non-amyloidogenic. The mutations are implicated in the etiology of several diseases, including amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis and carpal tunnel syndrome.
- Alternative Names
- Transthyretin; Prealbumin, Amyloidosis Type I; PALB; ATTR; TBPA; Epididymis Luminal Protein 111; Thyroxine-Binding Prealbumin
- Gene ID
- 7276
- UniProt ID
- P02766
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Datasheet
MSDS
COA
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