Anti-TYRO3 Antibody Prodrug, Protease Activated (2414)
CAT#: VS-1025-YC192
The Anti-TYRO3 Antibody Prodrug, Protease Activated (2414) is an antibody prodrug comprised of a recombinant human antibody targeting human TYRO3, linked to a masking peptide that conceals the active antigen-binding site via a protease-cleavable linker. The mask peptide is recombinantly attached to the amino terminus of either the light or heavy chain of the antibody, designed to block access to the antigen-binding site and physically prevent the antibody from binding to TYRO3 protein. Once the masking peptide is cleaved by matrix metalloproteinases (MMPs), the prodrug is activated, allowing the unmasked monoclonal antibody component to bind to TYRO3 effectively. TYRO3 is a receptor tyrosine kinase whose overexpression is associated with an aggressive phenotype and immunosuppression in various tumors, including melanoma. It promotes tumor cell survival and acts on immune cells to inhibit the anti-tumor response.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Glial cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71245/153510_B_7_5.jpg
Normal Tissue
Figure 2 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Low Intensity: Weak Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71245/153510_A_9_3.jpg
Normal Tissue
Figure 3 Kidney
Cells in glomeruli Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Cells in tubules Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71245/153510_A_7_5.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71245/153510_A_6_6.jpg
Normal Tissue
Figure 5 Skin
Epidermal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71245/153510_B_4_8.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (BEWO)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000092445-TYRO3
❮
❯
Specifications
- Host Animal
- Human
- Applications
- In situ zymography (ISZ), Cytotoxicity assay (Cyt), Functional assay
- Specificity
- Human TYRO3
- Target
- TYRO3
- Species Reactivity
- Human
- Isotype
- IgG
- Clone
- 2414
- Affinity Constant
- KD = 308 nM
- Masking Approach
- Affinity mask
- Mask
- A synthetic peptide
- Protease Cleavable Linker
- MMP-cleavable linker
- Protease Substrate
- MMPs
- Purification
- Protein A purified
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Target
- Introduction
- The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses.
- Alternative Names
- BYK; Dtk; RSE; Rek; Sky; Tif; Etk-2
- Gene ID
- 7301
- UniProt ID
- Q06418
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "Clone 2414"
- CAT
- Product Name
See other products for "TYRO3"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3539z | Mouse Anti-TYRO3 Recombinant Antibody (clone 41H2) | ELISA, IF, WB | Mouse IgG |
| HPAB-0027-DJB | Human Anti-TYRO3 Recombinant Antibody (clone 2414) | ELISA, FC | Human IgG |
| HPAB-0028-DJB | Human Anti-TYRO3 Recombinant Antibody (clone 2709) | ELISA, FC | Human IgG |
| HPAB-1524LY | Human Anti-TYRO3 Recombinant Antibody (clone 2710) | ELISA | Human IgG |
| HPAB-1525LY | Human Anti-TYRO3 Recombinant Antibody (clone 2717) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3735 | Rabbit Anti-TYRO3 Recombinant Antibody (clone DS3735AB) | WB, IHC, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0027-DJB-S(P) | Human Anti-TYRO3 Recombinant Antibody (clone 2414); scFv Fragment | ELISA | Human scFv |
| HPAB-0028-DJB-S(P) | Human Anti-TYRO3 Recombinant Antibody (clone 2709); scFv Fragment | ELISA | Human scFv |
| HPAB-1524LY-S(P) | Human Anti-TYRO3 Recombinant Antibody (clone 2710); scfv Fragment | ELISA | Human scfv |
| HPAB-1525LY-S(P) | Human Anti-TYRO3 Recombinant Antibody (clone 2717); scfv Fragment | ELISA | Human scfv |
| HPAB-1526LY-S(P) | Human Anti-TYRO3 Recombinant Antibody (clone 2411); scfv Fragment | ELISA | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0027-DJB-F(E) | Human Anti-TYRO3 Recombinant Antibody (clone 2414); Fab Fragment | ELISA | Human Fab |
| HPAB-0028-DJB-F(E) | Human Anti-TYRO3 Recombinant Antibody (clone 2709); Fab Fragment | ELISA | Human Fab |
| HPAB-1524LY-F(E) | Human Anti-TYRO3 Recombinant Antibody (clone 2710); Fab Fragment | ELISA | Human Fab |
| HPAB-1525LY-F(E) | Human Anti-TYRO3 Recombinant Antibody (clone 2717); Fab Fragment | ELISA | Human Fab |
| HPAB-1526LY-F(E) | Human Anti-TYRO3 Recombinant Antibody (clone 2411); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-096CN | Human Anti-TYRO3 Recombinant Antibody (clone 2410) | ELISA, FC | Human IgG |
| NS-097CN | Human Anti-TYRO3 Recombinant Antibody (clone 2718) | ELISA, FC | Human IgG |
| NS-096CN-F(E) | Human Anti-TYRO3 Recombinant Antibody (clone 2410); Fab Fragment | ELISA, FC | Human Fab |
| NS-097CN-F(E) | Human Anti-TYRO3 Recombinant Antibody (clone 2718); Fab Fragment | ELISA, FC | Human Fab |
| NS-096CN-S(P) | Human Anti-TYRO3 Recombinant Antibody (clone 2410); scFv Fragment | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2406 | Anti-TYRO3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7668 | Anti-Mouse TYRO3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7667 | Anti-Human TYRO3 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC436 | Recombinant Anti-TYRO3 Vesicular Antibody, EV Displayed (VS-0425-YC436) | ELISA, FC, Cell-uptake |
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