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    TYRO3

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    For Research Use Only. Not For Clinical Use.


    The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses.
    Protein class

    Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enhanced (Peritubular cells, Oligodendrocytes, Leydig cells, Excitatory neurons, Oligodendrocyte precursor cells)

    Immune cell specificity

    Immune cell enhanced (neutrophil)

    Cell line specificity

    Cell line enhanced (BEWO)

    Interaction

    Monomer and homodimer. Interacts (via N-terminus) with extracellular ligands TULP1 and GAS6 (By similarity). Interacts with PIK3R1; this interaction increases PI3-kinase activity (By similarity).

    Molecular function

    Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase

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