Mouse Anti-UBR5 Recombinant Antibody (UB140)
CAT#: VS-0326-YC140
The anti-UBR5 recombinant antibody (UB140) reacts with human UBR5. UBR5 (EDD1) is a massive HECT-domain E3 ligase involved in DNA repair, cell cycle control, and the DNA damage response. It ubiquitinates targets such as TopBP1 and p53. UBR5 signaling is often amplified in breast and ovarian cancers, where it drives tumor growth and resistance to DNA-damaging therapies. The anti-UBR5 antibody (UB140) has been tested in Immunohistochemistry (IHC).
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/53688/if_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Low cell line specificity
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000104517-UBR5
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG2a
- Specificity
- Human UBR5
- Species Reactivity
- Human
- Clone
- UB140
- Applications
- IHC
- Conjugate
- The unconjugated, Biotin and FITC formats are available.
Product Property
- Clonality
- Monoclonal
- Purification
- Affinity purified
- Format
- Liquid
- Buffer
- PBS
- Preservative
- 0.05% Sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Applications
- Application Notes
- IHC (1/100-1/200)
Target
- Alternative Names
- Ubiquitin Protein Ligase E3 Component N-Recognin 5; E3 Ubiquitin-Protein Ligase, HECT Domain-Containing 1; HECT-Type E3 Ubiquitin Transferase UBR5; Hyperplastic Discs Protein Homolog; Progestin-Induced Protein; EDD1; EDD; HYD; E3 Ubiquitin Protein Ligase, HECT Domain Containing, 1;
- Gene ID
- 51366
- UniProt ID
- O95071
- Long Name
- Ubiquitin Protein Ligase E3 Component N-Recognin 5
- Post Translation Modifications
- Unmodified
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "UBR5"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3768 | Rabbit Anti-UBR5 Recombinant Antibody (clone DS3768AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2423 | Anti-UBR5 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY7715 | Anti-Human UBR5 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS14-YC615 | AibGenesis™ Rabbit Anti-UBR5 Recombinant Antibody (AibG-Rb-BR411) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0326-XY666 | AibGenesis™ Rabbit Anti-UBR5 Recombinant Antibody (AibG-Rb-UB1841) | WB | Rabbit IgG |
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