Rabbit Anti-XRCC1 Recombinant Antibody (clone R02-0B0) (CAT#: VS3-FY2103)
This R02-0B0 recombinant monoclonal antibody is specifically engineered to detect human XRCC1. It cross-reacts with rat. Applications Tested: The XRCC1 antibody has been tested by western blot analysis of XRCC1 in PC-12 lysates and western blot analysis of XRCC1 in A549, MCF-7, 293T lysates.
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WB
Figure 1 Anti-XRCC1 Antibody (VS3-FY2103) in WB.
The XRCC1 expression in PC-12 lysates were detected using the anti-XRCC1 by western blot assay.
WB
Figure 2 Anti-XRCC1 Antibody (VS3-FY2103) in WB.
The XRCC1 expression in A549, MCF-7, 293T lysates were detected using the anti-XRCC1 by western blot assay.
Specifications
- Immunogen
- Synthetic peptide of human XRCC1
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human and Rat XRCC1
- Species Reactivity
- Human, Rat
- Clone
- R02-0B0
- Applications
- Western Blot, Immunofluorescence
- MW
- The calculated weight of the target protein is approximately 69 kDa, while the observed molecular weight stands at 82 kDa.
- Related Disease
- Cancer
Product Property
- Purification
- Affinity Purified
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- 50 mM Tris-Glycine (pH 7.4), 0.15 M NaCl, 40% glycerol, 0.05% BSA
- Preservative
- 0.01% Sodium azide
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/1000
Immunofluorescence: 1/50-1/200
Target
- Alternative Names
- X-Ray Repair Cross Complementing 1; XRCC1
- Gene ID
- 7515
- UniProt ID
- P18887
- Cellular Localization
- Chromosome, Nucleus
- Post Translation Modifications
- Phosphorylation of Ser-371 causes dimer dissociation.
Phosphorylation by CK2 promotes interaction with APTX and APLF.
(P18887-XRCC1_HUMAN)
Sumoylated. (P18887-XRCC1_HUMAN)
Glycosylation at Thr296, Thr440, Ser446, Ser447, and Thr453 (NX_P18887 [NX_P18887-1])
Modification sites at PhosphoSitePlus (P18887)
Glycosylation from GlyGen (P18887) 6 sites, 2 O-linked glycans (6 sites)
- Protein Refseq
- NP_006288.2
- Function
- Negatively regulates ADP-ribosyltransferase activity of PARP1 during base-excision repair in order to prevent excessive PARP1 activity.
Recognizes and binds poly-ADP-ribose chains: specifically binds auto-poly-ADP-ribosylated PARP1, limiting its activity.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
Rabbit Monoclonal Antibody Products
Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3628z | Mouse Anti-XRCC1 Recombinant Antibody (clone 41H8) | WB, IP, IF, IHC, ELISA | Mouse IgG2b |
| MOB-2157CT | Recombinant Mouse anti-Human XRCC1 Monoclonal antibody (44-3-6) | FC, ICC/IF, IHC-Fr, IHC-P, IP, WB | |
| MRO-1606-CN | Rabbit Anti-XRCC1 Recombinant Antibody (clone JA11-47) | WB, IHC | Rabbit IgG |
| ZG-0513F | Mouse Anti-XRCC1 Recombinant Antibody (ZG-0513F) | WB | Mouse IgG |
| VS3-XY3542 | Rabbit Anti-XRCC1 Recombinant Antibody (clone R05-7K6) | WB, IHC-P, ICC, IF | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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