Mouse Anti-YES1 Recombinant Antibody (VS3-CJ477)
CAT#: VS3-CJ477
This product is a mouse antibody that recognizes human YES1.
Specifications
- Immunogen
- Recombinant protein of human YES1
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Human YES1
- Species Reactivity
- Human
- Applications
- WB
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity purified
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS
- Preservative
- 0.09% Sodium Azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:4000).
Target
- Alternative Names
- Yes; c-yes; HsT441; P61-YES
- Gene ID
- 7525
- UniProt ID
- P07947
- Sequence Similarities
- Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
- Cellular Localization
- Cell membrane, Cytoplasm, Cytoskeleton, Membrane
- Post Translation Modifications
- Phosphorylation by CSK on the C-terminal tail maintains the enzyme in an inactive state. Autophosphorylation at Tyr-426 maintains enzyme activity by blocking CSK-mediated inhibition.
Palmitoylation at Cys-3 promotes membrane localization.
- Protein Refseq
- NP_005424.1
- Function
- Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, and differentiation. Stimulation by receptor tyrosine kinases (RTKs) including EGRF, PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the phosphorylated receptor, and activation and phosphorylation of downstream substrates. Upon EGFR activation, promotes the phosphorylation of PARD3 to favor epithelial tight junction assembly. Participates in the phosphorylation of specific junctional components such as CTNND1 by stimulating the FYN and FER tyrosine kinases at cell-cell contacts. Upon T-cell stimulation by CXCL12, phosphorylates collapsin response mediator protein 2/DPYSL2 and induces T-cell migration. Participates in CD95L/FASLG signaling pathway and mediates AKT-mediated cell migration. Plays a role in cell cycle progression by phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating the G1 phase. Also involved in G2/M progression and cytokinesis.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
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- Product Name
Secondary Antibody
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Recommended Dilution Buffer
- CAT
- Product Name
See other products for "YES1"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3691z | Mouse Anti-YES1 Recombinant Antibody (clone 22A8) | WB, ELISA | Mouse IgG1 |
| ZG-0451F | Mouse Anti-YES1 Recombinant Antibody (ZG-0451F) | WB, ELISA | Mouse IgG |
| VS3-FY1940 | Rabbit Anti-YES1 Recombinant Antibody (clone R07-8B3) | WB, IP | Rabbit IgG |
| VS3-FY2923 | Mouse Anti-YES1 Recombinant Antibody (VS3-FY2923) | WB | Mouse IgG |
| VS13-YC1234 | Rabbit Anti-YES1 Recombinant Antibody (VS13-YC1234) | WB, IHC-P, ICC, IF, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-3903 | Rabbit Anti-YES1 Recombinant Antibody (clone DS3903AB) | WB, IHC, ICC, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC376 | AbPlus™ Anti-YES1 Magnetic Beads (VS-0724-YC376) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY2505 | Anti-YES1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7982 | Anti-Mouse YES1 Immunohistochemistry Kit | IHC | |
| VS-0525-XY7981 | Anti-Human YES1 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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