Canine Anti-IL31 scFv-Fc Chimera (VS-0425-FY57) (CAT#: VS-0425-FY57)
This monoclonal antibody is specifically designed for the research of atopic dermatitis (AD) in dogs. It targets and neutralizes canine interleukin-31 (IL-31), a crucial cytokine in the inflammatory pathway of this condition.
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Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25657/60049_B_7_5.jpg
(Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25657/60049_B_7_5.jpg
Figure 2 Kidney
(Cells in glomeruli
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25657/60049_A_7_5.jpg
(Cells in glomeruli
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25657/60049_A_7_5.jpg
Figure 3 Lymph node
(Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25657/60049_A_8_8.jpg
(Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25657/60049_A_8_8.jpg
Figure 4 Spleen
(Cells in red pulp
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25657/60049_B_9_4.jpg
(Cells in red pulp
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25657/60049_B_9_4.jpg
Figure 5 RNA cell line category: Not detected
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000204671-IL31
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000204671-IL31
Specifications
- Host Species
- Canine
- Type
- Canine IgG2, scFv-Fc
- Specificity
- The antibody is a canine-specific antibody.
- Species Reactivity
- Canine
- Applications
- ELISA
- Related Disease
- Asthma
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 31; IL31
- Gene ID
- 386653
- UniProt ID
- Q6EBC2
- Long Name
- Interleukin 31
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn67 and Asn100
Glycosylation from GlyGen 2 sites
- Protein Refseq
- NP_001014358.1
- Function
- Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR.
May function in skin immunity.
Enhances myeloid progenitor cell survival in vitro.
Induces RETNLA and serum amyloid A protein expression in macrophages.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1474-sdAb | Recombinant Anti-Human IL31 VHH Single Domain Antibody | ICC, ChiP, FC, FA | Llama VHH |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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