Canine Anti-IL31 scFv-Fc Chimera (VS-0425-FY57)
CAT#: VS-0425-FY57
This monoclonal antibody is specifically designed for the research of atopic dermatitis (AD) in dogs. It targets and neutralizes canine interleukin-31 (IL-31), a crucial cytokine in the inflammatory pathway of this condition.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Neuropil
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25657/60049_B_7_5.jpg
Normal Tissue
Figure 2 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25657/60049_A_7_5.jpg
Normal Tissue
Figure 3 Lymph node
Germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25657/60049_A_8_8.jpg
Normal Tissue
Figure 4 Spleen
Cells in red pulp
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/25657/60049_B_9_4.jpg
RNA Expression
Figure 5 RNA cell line category: Not detected
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000204671-IL31
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Specifications
- Host Species
- Canine
- Type
- Canine IgG2, scFv-Fc
- Specificity
- The antibody is a canine-specific antibody.
- Species Reactivity
- Canine
- Applications
- ELISA
- Related Disease
- Asthma
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Interleukin 31; IL31
- Gene ID
- 386653
- UniProt ID
- Q6EBC2
- Long Name
- Interleukin 31
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn67 and Asn100
Glycosylation from GlyGen 2 sites
- Protein Refseq
- NP_001014358.1
- Function
- Activates STAT3 and possibly STAT1 and STAT5 through the IL31 heterodimeric receptor composed of IL31RA and OSMR.
May function in skin immunity.
Enhances myeloid progenitor cell survival in vitro.
Induces RETNLA and serum amyloid A protein expression in macrophages.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "IL31"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-1474-sdAb | Recombinant Anti-Human IL31 VHH Single Domain Antibody | ICC, ChiP, FC, FA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1385CQ | Mouse Anti-IL31 Recombinant Antibody (VMC200) | Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4266 | Rabbit Anti-Il31 Recombinant Antibody (clone SI348DS) | ELISA | Rabbit IgG |
| MOR-4617 | Rabbit Anti-IL31 Recombinant Antibody (clone TH130DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-419CQ | Anti-Canine IL31 Recombinant Antibody (TAB-419CQ) | ELISA, IHC, FC, IP, IF, FuncS | IgG2, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0131-LSX | Mouse Anti-IL31 Recombinant Antibody (HPAB-0131-LSX) | ELISA, WB | Mouse IgG |
| HPAB-0132-LSX | Mouse Anti-IL31 Recombinant Antibody (HPAB-0132-LSX) | ELISA, WB, Inhib | Mouse IgG |
| HPAB-0133-LSX | Mouse Anti-IL31 Recombinant Antibody (HPAB-0133-LSX) | ELISA, WB | Mouse IgG |
| HPAB-0134-LSX | Canine Anti-IL31 Recombinant Antibody (HPAB-0134-LSX) | ELISA, WB | Canine IgG |
| HPAB-0135-LSX | Canine Anti-IL31 Recombinant Antibody (HPAB-0135-LSX) | ELISA, WB | Canine IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0131-LSX-S(P) | Mouse Anti-IL31 Recombinant Antibody; scFv Fragment (HPAB-0131-LSX-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0132-LSX-S(P) | Mouse Anti-IL31 Recombinant Antibody; scFv Fragment (HPAB-0132-LSX-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0133-LSX-S(P) | Mouse Anti-IL31 Recombinant Antibody; scFv Fragment (HPAB-0133-LSX-S(P)) | ELISA, WB | Mouse scFv |
| HPAB-0134-LSX-S(P) | Canine Anti-IL31 Recombinant Antibody; scFv Fragment (HPAB-0134-LSX-S(P)) | ELISA, WB | Canine scFv |
| HPAB-0135-LSX-S(P) | Canine Anti-IL31 Recombinant Antibody; scFv Fragment (HPAB-0135-LSX-S(P)) | ELISA, WB | Canine scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0131-LSX-F(E) | Mouse Anti-IL31 Recombinant Antibody; Fab Fragment (HPAB-0131-LSX-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-0132-LSX-F(E) | Mouse Anti-IL31 Recombinant Antibody; Fab Fragment (HPAB-0132-LSX-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-0133-LSX-F(E) | Mouse Anti-IL31 Recombinant Antibody; Fab Fragment (HPAB-0133-LSX-F(E)) | ELISA, WB | Mouse Fab |
| HPAB-0134-LSX-F(E) | Canine Anti-IL31 Recombinant Antibody; Fab Fragment (HPAB-0134-LSX-F(E)) | ELISA, WB | Canine Fab |
| HPAB-0135-LSX-F(E) | Canine Anti-IL31 Recombinant Antibody; Fab Fragment (HPAB-0135-LSX-F(E)) | ELISA, WB | Canine Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-419CQ | Afuco™ Anti-IL31 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-419CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3526 | Anti-IL31 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC185 | Recombinant Anti-IL31 Eliminating Antibody, pH-Sensitive (VS-0625-YC185) | Antigen-Sweeping In Vivo. | Canine IgG2 kappa |
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