dAbs scaffold protein anti-human Insulin-like growth factor (IGF) (CAT#: SDS-L075)
The dAbs that bound insulin-like growth factor (IGF) was isolated from the library using Phage display techonology. After affinity maturation, dAbs variants were identified having affinities for insulin-like growth factor (IGF) as determined by biosensor technology. It's potential to be used in diagnostic, research and therapeutic applications.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human colon
(Immunohistochemical staining of human colon shows plasma positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/ihc_selected.jpg
(Immunohistochemical staining of human colon shows plasma positivity.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/ihc_selected.jpg
Figure 2 Colon
(Endothelial cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_7_3.jpg
(Endothelial cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_7_3.jpg
Figure 3 Rectum
(Glandular cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_3.jpg
(Glandular cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_3.jpg
Figure 4 Liver
(Hepatocytes Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_9_4.jpg
(Hepatocytes Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_9_4.jpg
Figure 5 Testis
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_6.jpg
(Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/48946/110992_A_4_6.jpg
Figure 6 RNA cell line category: Cell line enhanced (ASC diff, HDLM-2, K-562, Karpas-707, U-266/70)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000017427-IGF1/
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000017427-IGF1/
Specifications
- Scaffold Name
- dAbs
- Origin
- dAbs (human VH or VL single domain)
- Core Structure
- β-Sheet sandwich
- Variable Regions
- CDR 1, 2, 3
- Target
- Insulin-like growth factor (IGF)
- Species Reactivity
- human
- Expression Host
- BL21 (DE3) cells
- Applications
- ELISA; IHC; Microscopy; FC; WB; FuncS
Target
- Alternative Names
- dAbs (human VH or VL single domain); dAbs; MGF; IGFI; IGF-I
- Gene ID
- 3479
- UniProt ID
- P05019
Related Resources
Insulin Signaling Pathway
Endocrine Resistance
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1353z | Mouse Anti-IGF1 Recombinant Antibody (clone 23C1) | FC, IF, Neut | Mouse IgG1, κ |
| MOB-0151MZ | Recombinant Mouse Anti-IGF-I Somatomedin C Antibody (clone CM24) | RIA, ELISA | Mouse antibody |
| HPAB-0770-CN | Human Anti-IGF1 Recombinant Antibody (HPAB-0770-CN) | WB, FC | Human IgG1 |
| HPAB-0161-YJ | Human Anti-IGF1 Recombinant Antibody (HPAB-0161-YJ) | ELISA, Neut, FuncS | Human IgG1 |
| VS3-WK1283 | Mouse Anti-IGF1 Recombinant Antibody (VS3-WK1283) | IHC | Mouse IgG |
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