H-2 Db/Mouse S protein (CSLWNGPHL) MHC Tetramer
CAT#: MHC-YF947
This product is a MHC tetramer of biotinylated peptide/MHC complex composed S protein-derived peptide of CSLWNGPHL sequence covering 510-518 and H-2 Db molecule. The pMHC tetramer recognizes CD8 T cells and can be used in the MHC tetramer analysis of individual antigen-specific T cells.
Specifications
- Allele
- H-2 Db
- Class
- Class I
- MHC Species
- Mouse
- Antigen
- S protein
- Antigen Species
- MHV
- Peptide
- CSLWNGPHL
- Range
- 510-518
- Application
- FCM
Target
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Specific MHV Spike Detection
This H-2 Db tetramer loaded with the S protein peptide CSLWNGPHL was excellent for our coronavirus research. We detected specific CD8 T cells in MHV-infected mice. The reagent provided clear staining that allowed us to track the immune response.
Reliable Viral Spike Reagent
We used this product to analyze T cell immunity to the MHV Spike glycoprotein. The tetramer's specificity for the target epitope was high, and it enabled us to generate robust data on the kinetics of the antiviral response.
Q&As
-
What virus is the S protein peptide derived from in this product?
A: The peptide CSLWNGPHL (residues 510-518) is derived from the S protein (Spike glycoprotein) of the Murine hepatitis virus (MHV), which is a coronavirus that infects mice.
-
What is the function of the MHV Spike protein?
A: The MHV Spike protein attaches the virion to the host cell membrane by interacting with the host receptor (murine CEACAM1). It mediates viral entry and is a primary target for the immune response.
View the frequently asked questions answered by Creative Biolabs Support.
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Downloadable Resources
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Datasheet
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Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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