Anti-B. Anthracis Anthrax Protective Antigen (Raxibacumab)
CAT#: TAB-224
Recombinant monoclonal antibody to Bacillus anthracis protective antigen. Raxibacumab is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.
Specifications
- Immunogen
- The details of the immunogen for this antibody are not available.
- Host Species
- Human
- Derivation
- Human
- Type
- IgG1 - lambda
- Specificity
- Tested positive against native B. anthracis antigen.
- Species Reactivity
- B. anthracis
- Applications
- FC, IP, ELISA, Neut, FuncS, IF, WB
- Trade name
- abthrax
- CAS
- 565451-13-0
- Generic Name
- Raxibacumab
- ATC Code
- J06BB18
- MW
- 142.93 kDa
- Related Disease
- Anthrax inhalation
Product Property
- Purity
- >95.0% as determined by Analysis by RP-HPLC & analysis by SDS-PAGE.
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Applications
- Application Notes
- The B. anthracis PA antibody has been reported in applications of Inhib, PK.
Inhibition: Doses of raxibacumab of 10 mg per kilogram or higher provided a significant benefit with respect to the primary end point, the 14-day survival rate (80 to 100%, as compared with 0% with placebo; P<0.001).
Target
- Alternative Names
- Raxibacumab;abthrax;565451-13-0;PA;anthrax PA;Anthrax Protective Antigen;Anthrax toxins translocating protein;Bacillus anthracis Protective Antigen;PA 83;PA;PA83;Pag;PagA;Protective antigen
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Biosimilar Overview
Please refer to Raxibacumab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Raxibacumab.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
See other products for "Raxibacumab"
Afuco™ Anti-B. anthracis PA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-224)This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Bacillus anthracis protective antigen. It is a human monoclonal antibody intended for the prophylaxis and treatment of inhaled anthrax. Its efficacy has been proven in rabbits and monkeys.
DrugMonitor™ Anti-Raxibacumab Antibody (VS-1224-YC984)Raxibacumab is a monoclonal antibody used alongside antibacterial regimens for treating inhalational anthrax caused by Bacillus anthracis and for preventive treatment when necessary. The DrugMonitor™ Anti-Raxibacumab Antibody (VS-1224-YC984) is an anti-drug antibody (ADA) against Raxibacumab. This drug-based antibody is raised in mice immunized with the Raxibacumab. The anti-Raxibacumab antibody may be used in ELISA, pharmacokinetics (PK), and pharmacodynamics (PD) analyses, or serves as a reference standard in ADA assays. It also is an excellent tool for therapeutic drug monitoring, allowing to evaluate the drug efficacy and determine the drug concentration of the Raxibacumab in samples.
See other products for "B. anthracis PA"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-194-VHH | Recombinant Anti-B. anthracis PA VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-97 | Recombinant Anti-B. anthracis PA Antibody | ELISA, IF, FuncS | IgG |
| MRO-513-MZ | Mouse Anti-B. anthracis PA Recombinant Antibody (clone 7825) | ELISA | Mouse IgG |
| HPAB-0747-YJ | Human Anti-B. anthracis PA Recombinant Antibody (W1) | ELSIA, Neut | Chimeric (chimpanzee/human) IgG1, κ |
| HPAB-0748-YJ | Human Anti-B. anthracis PA Recombinant Antibody (W2) | ELSIA, Neut | Chimeric (chimpanzee/human) IgG1, κ |
| ZG-0292F | Mouse Anti-B. anthracis PA Recombinant Antibody (ZG-0292F) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-97-F(E) | Recombinant Anti-B. anthracis PA Antibody Fab Fragment | RIA, IP, FuncS | Fab |
| HPAB-0780-CN-F(E) | Mouse Anti-B. anthracis PA Recombinant Antibody; Fab Fragment (HPAB-0780-CN-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-0781-CN-F(E) | Mouse Anti-B. anthracis PA Recombinant Antibody; Fab Fragment (HPAB-0781-CN-F(E)) | ELISA, Neut | Mouse Fab |
| HPAB-0747-YJ-F(E) | Human Anti-B. anthracis PA Recombinant Antibody (W1); Fab Fragment | ELISA, Neut | Chimeric (chimpanzee/human) Fab |
| HPAB-0748-YJ-F(E) | Human Anti-B. anthracis PA Recombinant Antibody (W2); Fab Fragment | ELISA, WB, Neut, FuncS | Chimeric (chimpanzee/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-97-S(P) | Recombinant Anti-B. anthracis PA Antibody scFv Fragment | WB, FC, FuncS | scFv |
| HPAB-0780-CN-S(P) | Mouse Anti-B. anthracis PA Recombinant Antibody; scFv Fragment (HPAB-0780-CN-S(P)) | ELISA, Neut | Mouse scFv |
| HPAB-0781-CN-S(P) | Mouse Anti-B. anthracis PA Recombinant Antibody; scFv Fragment (HPAB-0781-CN-S(P)) | ELISA, Neut | Mouse scFv |
| HPAB-0747-YJ-S(P) | Chimpanzee Anti-PA Recombinant Antibody (W1); scFv Fragment | ELISA, Neut | Chimpanzee scFv |
| HPAB-0748-YJ-S(P) | Chimpanzee Anti-PA Recombinant Antibody (W2); scFv Fragment | ELISA, WB, Neut, FuncS | Chimpanzee scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| EPAF-0387LC | Recombinant Mouse Anti-B. anthracis PA Antibody (F20G75) | BL, ELISA | IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-224 | Afuco™ Anti-B. anthracis PA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-224) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| AFC-TAB-440CQ | Afuco™ Anti-PA ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-440CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
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