Anti-IL-13-Rα2-mc-MMAE ADC
CAT#: ADC-028CL
This ADC product is composed of an anti-IL-13-Rα2 antibody conjugated via mc linker to MMAE. It has demonstrated a response in IL-13-Ra2 expressing cancer treatment.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line BJ
Immunofluorescent staining of human cell line BJ shows localization to nucleoplasm & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45831/1866_G1_31_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to cell junctions.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/67363/1754_D2_3_cr57f3cf6655f7f_selected.jpg
RNA Expression
Figure 3 RNA cell line category: Group enriched (PC-3, U-2197, U-251 MG, U-87 MG)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000123496-IL13RA2
❮
❯
Specifications
- Antibody Overview
- Humanized Anti-IL-13-Ra2 lgG1 Antibody
- Linker
- Mc (maleimidocaproyl)
- Linker Class/Description
- Class: Noncleavable linkers
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- N,2-dimethylalanyl-N-{(1 S,2R)-4-{(2S)-2-[(1 R,2R)-3-{[(1 S)-1-carboxy-2-phenylethyl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-2-methoxy-1-[(1 S)-1-methylpropyl]-4-oxobutyl}-N-methyl-L-valinamide, trifluoroacetic acid salt
Target
- Introduction
- The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]
- Alternative Names
- IL13RA2; interleukin 13 receptor, alpha 2; CT19; IL-13R; IL13BP; CD213A2; interleukin-13 receptor subunit alpha-2; IL-13RA2; IL-13R-alpha-2; IL-13R subunit alpha-2; cancer/testis antigen 19; IL-13 receptor subunit alpha-2; interleukin 13 binding protein; interleukin-13-binding protein; interleukin 13 receptor alpha 2 chain;
- Gene ID
- 3598
- UniProt ID
- Q14627
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for ADC-028CL. Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "IL13RA2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-555 | Recombinant Anti-human IL13RA2 Antibody | WB, Neut, FuncS | IgG |
| MHH-555 | Recombinant Human Anti-human IL13RA2 Antibody | ELISA, IP, FuncS | IgG |
| MOB-0783CT | Recombinant Mouse anti-Human IL13RA2 Monoclonal antibody (EML442) | FC, ICC, IF, IHC-Fr, IHC-P, IP, WB | |
| HPAB-0999WJ | Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL_13Ra 2-7) | ELISA, FC, IHC | Mouse IgG |
| HPAB-J0128-YC | Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL-13R alpha 2-7) | ELISA, FC | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-555-F(E) | Recombinant Anti-human IL13RA2 Antibody Fab Fragment | IP, IF, FuncS | Fab |
| MHH-555-F(E) | Recombinant Human Anti-human IL13RA2 Antibody Fab Fragment | IP, IF, FuncS | Fab |
| HPAB-0999WJ-F(E) | Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL_13Ra 2-7); Fab Fragment | ELISA, FC, IHC | Mouse Fab |
| HPAB-J0128-YC-F(E) | Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL-13R alpha 2-7); Fab Fragment | ELISA, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-555-S(P) | Recombinant Anti-human IL13RA2 Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
| MHH-555-S(P) | Recombinant Human Anti-human IL13RA2 Antibody scFv Fragment | IF, FC, Biosensors, FuncS | scFv |
| HPAB-0999WJ-S(P) | Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL_13Ra 2-7); scFv Fragment | ELISA, FC, IHC | Mouse scFv |
| HPAB-J0128-YC-S(P) | Mouse Anti-IL13RA2 Recombinant Antibody (clone FMMU-IL-13R alpha 2-7); scFv Fragment | ELISA, FC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G040E | IL-13-PE immunotoxin | Cytotoxicity assay, Function study | |
| AGTO-G040D | IL-13-DT immunotoxin | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0154CL | Mouse Anti-IL13RA2 Recombinant Antibody (TAB-0154CL) | ELISA, Internalization, BI, FuncS | Mouse IgG |
| TAB-0155CL | Mouse Anti-IL13RA2 Recombinant Antibody (TAB-0155CL) | ELISA, Internalization, BI, FuncS | Mouse IgG |
| TAB-0156CL | Human Anti-IL13RA2 Recombinant Antibody (TAB-0156CL) | ELISA, Internalization, BI, FuncS | Chimeric (mouse/human) IgG |
| TAB-0157CL | Human Anti-IL13RA2 Recombinant Antibody (TAB-0157CL) | ELISA, Internalization, BI, FuncS | Chimeric (mouse/human) IgG |
| TAB-024ZJ-F(E) | Mouse Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-024ZJ-F(E)) | ELISA, WB, IP, IF, IHC, FC | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-0158CL-F(E) | Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-0158CL-F(E)) | ELISA, Internalization, BI, FuncS | Humanized Fab |
| TAB-0159CL-F(E) | Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-0159CL-F(E)) | ELISA, Internalization, BI, FuncS | Humanized Fab |
| TAB-0160CL-F(E) | Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-0160CL-F(E)) | ELISA, Internalization, BI, FuncS | Humanized Fab |
| TAB-0161CL-F(E) | Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-0161CL-F(E)) | ELISA, Internalization, BI, FuncS | Humanized Fab |
| TAB-0162CL-F(E) | Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-0162CL-F(E)) | ELISA, Internalization, BI, FuncS | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-025ZJ | Mouse Anti-IL13RA2 Recombinant Antibody (TAB-025ZJ) | ELISA, WB, IP, IF, IHC, FC | Mouse IgM, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-383CQ | Human Anti-IL13RA2 Recombinant Antibody (TAB-383CQ) | ELISA | Human IgG |
| TAB-383CQ-S(P) | Human Anti-IL13RA2 Recombinant Antibody; scFv Fragment (TAB-383CQ-S(P)) | ELISA | Human scFv |
| TAB-383CQ-F(E) | Human Anti-IL13RA2 Recombinant Antibody; Fab Fragment (TAB-383CQ-F(E)) | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0279MZ | Chicken Anti-Interleukin-13 Receptor α2 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1190CQ | Mouse Anti-IL13RA2 Recombinant Antibody (VMC188) | FC, ELISA, IHC, Block | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4241 | Rabbit Anti-IL13RA2 Recombinant Antibody (clone SI320DS) | ELISA | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MHC-CN0905 | PE-A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer | FCM, IHC | |
| MHC-CN0906 | APC-A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer | FCM, IHC | |
| MHC-CN0907 | FITC-A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer | FCM, IHC | |
| MHC-CN0908 | A*24:02/Human IL13RA2 (VYYNWQYLL) MHC Tetramer | FCM, IHC | |
| MHC-YF498 | A*02:01/Human IL13R (ALPFGFILV) MHC Pentamer | FCM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY108 | Mouse Anti-IL13RA2 (clone 2-7) scFv-Fc Chimera | ELISA, FC, IHC | Mouse IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC351 | Recombinant Anti-IL13RA2 Vesicular Antibody, EV Displayed (VS-0425-YC351) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3486 | Anti-IL13RA2 Immunohistochemistry Kit | IHC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: WB, ELISA, IP, FC, FuncS, Neut, IF
Application: Inhib, Cyt
Application: WB, ELISA, FuncS, IB, FC, SPR, Apop
Application: ELISA, IHC, FC, IP, IF, Inhib
Application: ELISA, Inhib, FuncS
-2.png)
Application: ELISA
Application: IF, IP, Neut, FuncS, ELISA, FC
Application: ELISA, FC, Inhib, IHC-Fr, WB, IP
-3.jpg)
Application: IB, FC, ELISA, FuncS
Application: ELISA, FC, FuncS
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
