Anti-IL-13-Rα2-MC-VC-PABC-MMAE ADC

CAT#: ADC-034CL

This ADC product is composed of an anti-IL-13-Rα2 antibody conjugated via MC-VC-PABC linker to MMAE. It has demonstrated a response in IL-13-Ra2 expressing cancer treatment.

Gene Expression
Figure 1 IF staining of human cell line BJ Figure 2 IF staining of human cell line U-2 OS Figure 3 RNA cell line category: Group enriched (PC-3, U-2197, U-251 MG, U-87 MG)

Specifications

  • Antibody Overview
  • Humanized Anti-IL-13-Ra2 lgG1 Antibody
  • Linker
  • MC-VC-PABC (maleimidocaproyl-valine-citrulline-p-aminobenzoyloxycarbonyl)
  • Linker Class/Description
  • Class: Enzymatically cleavable linkers-Peptide linkers
    Description: peptide linkers, belonging to Enzymatically cleavable linkers, combine greater systemic stability with rapid enzymatic release of the drug in the target cell. The scission of peptidic bonds relies on lysosomal proteolytic enzymes, which have very low activities in blood due to endogenous inhibitors and the unfavorably high pH value of blood.
  • Drug
  • 2-methylalanyl-N-[(3R,4S,5S)-1-{(2S)-2-[(1R,2R)-3-{[(1S,2R)-1-hydroxy-1-phenylpropan-2-yl]amino}-1-methoxy-2-methyl-3-oxopropyl]pyrrolidin-1-yl}-3-methoxy-5-methyl-1-oxoheptan-4-yl]-N-methyl-L-valinamide

Target

  • Introduction
  • The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal mediator. It is reported to play a role in the internalization of IL13. [provided by RefSeq, Jul 2008]
  • Alternative Names
  • IL13RA2; interleukin 13 receptor, alpha 2; CT19; IL-13R; IL13BP; CD213A2; interleukin-13 receptor subunit alpha-2; IL-13RA2; IL-13R-alpha-2; IL-13R subunit alpha-2; cancer/testis antigen 19; IL-13 receptor subunit alpha-2; interleukin 13 binding protein; interleukin-13-binding protein; interleukin 13 receptor alpha 2 chain;
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