Human Anti-AOC3 (clone Timolumab) scFv-Fc Chimera
CAT#: VS-0425-FY65
This scFv-Fc construct targets AOC3 (Amine oxidase, copper-containing 3), an enzyme involved in the degradation of biogenic amines. It has potential applications in cancer therapy and modulation of the tumor microenvironment.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol & the Golgi apparatus.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/980/if_selected.jpg
Normal Tissue
Figure 2 Lung
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/980/2500_A_1_4_val_selected.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/980/2500_A_7_3.jpg
Normal Tissue
Figure 4 Soft tissue
Fibroblasts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/25797/57908_B_2_8.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enriched (ASC diff)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000131471-AOC3
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Specifications
- Immunogen
- Human AOC3/VAP1 as an immunogen.
- Host Species
- Human
- Type
- Human IgG4, scFv-Fc
- Specificity
- Human AOC3
- Species Reactivity
- Human
- Clone
- Timolumab
- Applications
- ELISA
- Related Disease
- Diabetes mellitus
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Amine Oxidase, Copper Containing 3; Semicarbazide-Sensitive Amine Oxidase; Vascular Adhesion Protein 1; Copper Amine Oxidase; EC 1.4.3.21; VAP-1; SSAO
- Gene ID
- 8639
- UniProt ID
- Q16853
- Long Name
- Amine Oxidase, Copper Containing 3
- Sequence Similarities
- Belongs to the copper/topaquinone oxidase family.
- Cellular Localization
- Cell membrane; Single-pass type II membrane protein
- Post Translation Modifications
- Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
N- and O-glycosylated.
Glycosylation at Asn592, Asn618, Asn666, Asn137, Thr212, Asn232, and Asn294
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect AOC3_HUMAN (1502)
Glycosylation from GlyGen 10 sites, 43 N-linked glycans (3 sites), 1 O-linked glycan
- Protein Refseq
- XP_011523721.1; XP_011523722.1; XP_024306783.1; XP_047292938.1; XP_047292939.1
- Function
- Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia.
Has a preference for the primary monoamines methylamine and benzylamine.
Could also act on 2-phenylethylamine but much less efficiently.
At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "AOC3"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-261 | Anti-Human AOC3 Recombinant Antibody (Vapaliximab) | WB, FC, IP, ELISA, Neut, FuncS, IF | IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-137 | Anti-Human AOC3 Recombinant Antibody (TAB-137) | Neut, ELISA, IF, IP, FuncS, FC, ICC | IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-045CL | Human Anti-AOC3 Recombinant Antibody (TAB-045CL) | ELISA | Human IgG |
| TAB-455CQ | Anti-Human AOC3 Recombinant Antibody (Timolumab) | ELISA, IHC, FC, IP, IF, FuncS | IgG4, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0189 | Hi-Affi™ Rabbit Anti-AOC3 Recombinant Antibody (clone DS189AB) | IP, IHC-P, WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NS-098CN | Human Anti-AOC3 Recombinant Antibody (clone Mo2D10) | ELISA, FC, IF, IHC, Inhib, FuncS | Human IgG1, κ |
| NS-099CN | Human Anti-AOC3 Recombinant Antibody (clone BTT-1002) | ELISA, FC, IF, IHC, Inhib, FuncS | Human IgG |
| NS-098CN-F(E) | Human Anti-AOC3 Recombinant Antibody (clone Mo2D10); Fab Fragment | ELISA, FC, IF, IHC | Human Fab |
| NS-099CN-F(E) | Human Anti-AOC3 Recombinant Antibody (clone BTT-1002); Fab Fragment | ELISA, FC, IF, IHC | Human Fab |
| NS-098CN-S(P) | Mouse Anti-AOC3 Recombinant Antibody (clone Mo2D10); scFv Fragment | ELISA, FC, IF, IHC | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1627LY-S(P) | Mouse Anti-AOC3 Recombinant Antibody (clone 1G3); scfv Fragment | ELISA | Mouse scfv |
| HPAB-1628LY-S(P) | Mouse Anti-AOC3 Recombinant Antibody (clone 3F10); scfv Fragment | ELISA | Mouse scfv |
| HPAB-1629LY-S(P) | Mouse Anti-AOC3 Recombinant Antibody (clone 3G6); scfv Fragment | ELISA | Mouse scfv |
| HPAB-0966-FY-F(E) | Human Anti-AOC3 Recombinant Antibody; Fab Fragment (HPAB-0966-FY-F(E)) | IF | Human Fab |
| HPAB-0967-FY-F(E) | Human Anti-AOC3 Recombinant Antibody; Fab Fragment (HPAB-0967-FY-F(E)) | IF | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1627LY | Mouse Anti-AOC3 Recombinant Antibody (clone 1G3) | ELISA | Mouse IgG |
| HPAB-0966-FY | Human Anti-AOC3 Recombinant Antibody (HPAB-0966-FY) | IF | Human IgG |
| HPAB-0967-FY | Human Anti-AOC3 Recombinant Antibody (HPAB-0967-FY) | IF | Human IgG |
| HPAB-0968-FY | Human Anti-AOC3 Recombinant Antibody (HPAB-0968-FY) | IF | Human IgG |
| HPAB-0969-FY | Human Anti-AOC3 Recombinant Antibody (HPAB-0969-FY) | IF | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-1627LY-F(E) | Mouse Anti-AOC3 Recombinant Antibody (clone 1G3); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0966-FY-S(P) | Human Anti-AOC3 Recombinant Antibody; scFv Fragment (HPAB-0966-FY-S(P)) | IF | Human scFv |
| HPAB-0967-FY-S(P) | Human Anti-AOC3 Recombinant Antibody; scFv Fragment (HPAB-0967-FY-S(P)) | IF | Human scFv |
| HPAB-0968-FY-S(P) | Human Anti-AOC3 Recombinant Antibody; scFv Fragment (HPAB-0968-FY-S(P)) | IF | Human scFv |
| HPAB-0969-FY-S(P) | Human Anti-AOC3 Recombinant Antibody; scFv Fragment (HPAB-0969-FY-S(P)) | IF | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-261 | Afuco™ Anti-AOC3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-261) | FC, IP, ELISA, Neut, FuncS | ADCC enhanced antibody |
| AFC-TAB-455CQ | Afuco™ Anti-AOC3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-455CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-137 | Afuco™ Anti-AOC3 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-137) | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY15 | AbPlus™ Anti-AOC3 Magnetic Beads (2D10) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY422 | Anti-AOC3 Immunohistochemistry Kit | IHC | |
| VS-0525-XY423 | Anti-Mouse AOC3 Immunohistochemistry Kit | IHC |
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