Human Anti-AOC3 (clone Timolumab) scFv-Fc Chimera (CAT#: VS-0425-FY65)

• Immunogen
• Human AOC3/VAP1 as an immunogen.

• Host Species
• Human

• Type
• Human IgG4, scFv-Fc

• Specificity
• Human AOC3

• Species Reactivity
• Human

• Clone
• Timolumab

• Applications
• ELISA

• Related Disease
• Diabetes mellitus

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Amine Oxidase, Copper Containing 3; Semicarbazide-Sensitive Amine Oxidase; Vascular Adhesion Protein 1; Copper Amine Oxidase; EC 1.4.3.21; VAP-1; SSAO

• Gene ID
• 8639

• UniProt ID
• Q16853

• Long Name
• Amine Oxidase, Copper Containing 3

• Sequence Similarities
• Belongs to the copper/topaquinone oxidase family.

• Cellular Localization
• Cell membrane; Single-pass type II membrane protein

• Post Translation Modifications
• Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue.
  N- and O-glycosylated.
  Glycosylation at Asn592, Asn618, Asn666, Asn137, Thr212, Asn232, and Asn294
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect AOC3_HUMAN (1502)
  Glycosylation from GlyGen 10 sites, 43 N-linked glycans (3 sites), 1 O-linked glycan

• Protein Refseq
• XP_011523721.1; XP_011523722.1; XP_024306783.1; XP_047292938.1; XP_047292939.1

• Function
• Catalyzes the oxidative deamination of primary amines to the corresponding aldehydes with the concomitant production of hydrogen peroxide and ammonia.
  Has a preference for the primary monoamines methylamine and benzylamine.
  Could also act on 2-phenylethylamine but much less efficiently.
  At endothelial cells surface can also function as a cell adhesion protein that participates in lymphocyte extravasation and recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion.

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