Human Anti-CD16 (clone B88-9) scFv-Fc Chimera
CAT#: VS-0325-FY61
Anti-CD16 scFv-Fc antibodies are engineered proteins designed to specifically bind to the CD16 antigen, which is a receptor found on the surface of various immune cells, including natural killer (NK) cells, macrophages, and neutrophils. The term "scFv-Fc" refers to a single-chain variable fragment (scFv) fused to the Fc region of an immunoglobulin. This structure combines the specificity of an antibody's variable region with the effector functions associated with the Fc region, leading to enhanced therapeutic and diagnostic applications.
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CD16
- Species Reactivity
- Human
- Clone
- B88-9
- Applications
- Immunoprecipitation, Flow Cytometry, Immunofluorescence
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- CD16; FCGR3
- Long Name
- CD16
- Cellular Localization
- Cell membrane; Secreted
- Post Translation Modifications
- Glycosylated.
Contains high mannose- and complex-type oligosaccharides.
Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.
Undergoes rapid ectodomain shedding upon NK cell stimulation.
The soluble form is produced by a proteolytic cleavage mediated by ADAM17.
Repeated stimulation causes receptor shedding, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells while avoiding activation-induced NK cell apoptosis.
Phosphorylated at RSSTR motif by PKC.
The relevant physiological PKCs might be PRKCI, PRKCG, PRKCE, PRKCH and PRKCQ.
Glycosylation at Asn56, Asn63, Asn92, Asn180, and Asn187
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect FCG3A_HUMAN (3000)
Glycosylation from GlyGen 7 sites, 99 N-linked glycans (6 sites)
- Protein Refseq
- XP_047305399.1; XP_047305400.1; NP_000560.7; NP_001121064.2; NP_001121065.1
- Function
- CD16 (Fc gamma receptor III) is an Fc receptor expressed on natural killer cells and neutrophils. It mediates antibody-dependent cellular cytotoxicity (ADCC) and plays a crucial role in the immune response.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Protocol & Troubleshooting
We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
See other products for "Clone B88-9"
- CAT
- Product Name
See other products for "CD16"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4015 | Hi-Affi™ Rabbit Anti-CD16 Recombinant Antibody (clone SI78DS) | FC | Rabbit IgG |
| MOR-4016 | Hi-Affi™ Rabbit Anti-CD16 Recombinant Antibody (clone SI79DS) | FC | Rabbit IgG |
| MOR-4017 | Hi-Affi™ Rabbit Anti-CD16 Recombinant Antibody (clone SI80DS) | FC | Rabbit IgG |
| MOR-4018 | Hi-Affi™ Rabbit Anti-CD16 Recombinant Antibody (clone SI81DS) | WB, ELISA | Rabbit IgG |
| MOR-4019 | Hi-Affi™ Rabbit Anti-CD16 Recombinant Antibody (clone SI82DS) | FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0697-YJ-VHH | Camelid Anti-CD16 Recombinant Antibody (HPAB-0697-YJ-VHH) | ELISA, FC | Camelid VHH |
| NBD-0014-YJ-VHH | Camelid Anti-CD16 Recombinant Single Domain Antibody (NBD-0014-YJ-VHH) | ELISA, FuncS | Camelid VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1632CQ | Human Anti-CD16 Recombinant Antibody (clone DJ130c) | IP, WB, FC, IHC | Human IgG1 |
| FAMAB-1633CQ | Human Anti-CD16 Recombinant Antibody (clone B88-9) | IP, FC, IF | Human IgG1 |
| FAMAB-1737CQ | Rat Anti-CD16 Recombinant Antibody (clone YFC 120.5) | FC | Rat IgG2b |
| ZG-0849F | Mouse Anti-CD16 Recombinant Antibody (clone J5511) | FC | Mouse IgG1 |
| VS11-QX24 | Mouse Anti-CD16 Recombinant Antibody (clone 3G8) | FC, SPR, Depletion, IP, IHC, Block | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY353 | Anti-CD16 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC26 | Recombinant Anti-CD16 Biparatopic Antibody, Tandem scFv (Clone DJ130c x Clone B88-9) | FC, IP | Tandem scFv |
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