Human Anti-CD16 (clone B88-9) scFv-Fc Chimera (CAT#: VS-0325-FY61)
Anti-CD16 scFv-Fc antibodies are engineered proteins designed to specifically bind to the CD16 antigen, which is a receptor found on the surface of various immune cells, including natural killer (NK) cells, macrophages, and neutrophils. The term "scFv-Fc" refers to a single-chain variable fragment (scFv) fused to the Fc region of an immunoglobulin. This structure combines the specificity of an antibody's variable region with the effector functions associated with the Fc region, leading to enhanced therapeutic and diagnostic applications.
Specific Inquiry
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CD16
- Species Reactivity
- Human
- Clone
- B88-9
- Applications
- Immunoprecipitation, Flow Cytometry, Immunofluorescence
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- CD16; FCGR3
- Long Name
- CD16
- Cellular Localization
- Cell membrane; Secreted
- Post Translation Modifications
- Glycosylated.
Contains high mannose- and complex-type oligosaccharides.
Glycosylation at Asn-180 is mandatory for high affinity binding to the Fc and for discrimination between fucosylated and afucosylated IgG glycoforms.
Undergoes rapid ectodomain shedding upon NK cell stimulation.
The soluble form is produced by a proteolytic cleavage mediated by ADAM17.
Repeated stimulation causes receptor shedding, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells while avoiding activation-induced NK cell apoptosis.
Phosphorylated at RSSTR motif by PKC.
The relevant physiological PKCs might be PRKCI, PRKCG, PRKCE, PRKCH and PRKCQ.
Glycosylation at Asn56, Asn63, Asn92, Asn180, and Asn187
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect FCG3A_HUMAN (3000)
Glycosylation from GlyGen 7 sites, 99 N-linked glycans (6 sites)
- Protein Refseq
- XP_047305399.1; XP_047305400.1; NP_000560.7; NP_001121064.2; NP_001121065.1
- Function
- CD16 (Fc gamma receptor III) is an Fc receptor expressed on natural killer cells and neutrophils. It mediates antibody-dependent cellular cytotoxicity (ADCC) and plays a crucial role in the immune response.
Recommended Products
Isotype Control
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4015 | Hi-Affi™ Rabbit Anti-CD16 Recombinant Antibody (clone SI78DS) | FC | Rabbit IgG |
| MOR-4016 | Hi-Affi™ Rabbit Anti-CD16 Recombinant Antibody (clone SI79DS) | FC | Rabbit IgG |
| MOR-4017 | Hi-Affi™ Rabbit Anti-CD16 Recombinant Antibody (clone SI80DS) | FC | Rabbit IgG |
| MOR-4018 | Hi-Affi™ Rabbit Anti-CD16 Recombinant Antibody (clone SI81DS) | WB, ELISA | Rabbit IgG |
| MOR-4019 | Hi-Affi™ Rabbit Anti-CD16 Recombinant Antibody (clone SI82DS) | FC | Rabbit IgG |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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