Human Anti-CNR1 scFv-Fc Chimera (VS-0425-FY72)
CAT#: VS-0425-FY72
CNR1 (Cannabinoid receptor 1) is a G-protein-coupled receptor involved in pain signaling. This scFv-Fc construct is designed for potential use in pain management and neurodegenerative diseases by targeting CNR1.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line AF22
Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & actin filaments.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42256/1595_A8_2_selected.jpg
Normal Tissue
Figure 2 Low expression in liver
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_7_4_val_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuropil Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_B_8_5.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_7_3.jpg
Normal Tissue
Figure 5 Testis
Sertoli cells Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_6_6.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (ASC diff, HSkMC)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118432-CNR1
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Specifications
- Immunogen
- The immunogen is HEK293 cells have been transfected to express the proteins PADRE-hCB1 and E3K-hCB1.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CNR1
- Species Reactivity
- Human
- Applications
- Inhibition, Antagonist
- Related Disease
- Cannabis Dependence and Anxiety
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- In the GTP-Eu assay, the antibody antagonized the endogenous CB1 agonist anandamide with an IC₅₀ value of approximately 10.14 nM.
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Cannabinoid Receptor 1; Cannabinoid Receptor 1 (Brain); CANN6; CB-R; CNR; CB1
- Gene ID
- 1268
- UniProt ID
- P21554
- Long Name
- Cannabinoid Receptor 1
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane, Membrane raft, Mitochondrion outer membrane, Cell projection, axon, Presynapse
- Post Translation Modifications
- Palmitoylation at Cys-415 is important for recruitment at plasma membrane and lipid rafts and association with G protein alpha subunits.
Glycosylation at Asn77 and Asn83
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites
- Protein Refseq
- XP_047274127.1; XP_047274128.1; XP_047274129.1; XP_054210179.1; XP_054210180.1
- Function
- Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CNR1"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1492CL | Human Anti-CNR1 Recombinant Antibody (TAB-1492CL) | FC, FuncS | Human IgG |
| TAB-1492CL-S(P) | Human Anti-CNR1 Recombinant Antibody; scFv Fragment (TAB-1492CL-S(P)) | FC, FuncS | Human scFv |
| TAB-1492CL-F(E) | Human Anti-CNR1 Recombinant Antibody; Fab Fragment (TAB-1492CL-F(E)) | FC, FuncS | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2987LY | Human Anti-CNR1 Recombinant Antibody (HPAB-2987LY) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) IgG |
| HPAB-2988LY | Human Anti-CNR1 Recombinant Antibody (HPAB-2988LY) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) IgG |
| HPAB-2989LY | Human Anti-CNR1 Recombinant Antibody (HPAB-2989LY) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) IgG |
| HPAB-2990LY | Human Anti-CNR1 Recombinant Antibody (HPAB-2990LY) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) IgG |
| HPAB-2991LY | Human Anti-CNR1 Recombinant Antibody (HPAB-2991LY) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2987LY-S(P) | Mouse Anti-CNR1 Recombinant Antibody; scFv Fragment (HPAB-2987LY-S(P)) | ELISA, WB, FC, FuncS | Mouse scFv |
| HPAB-2988LY-S(P) | Mouse Anti-CNR1 Recombinant Antibody; scFv Fragment (HPAB-2988LY-S(P)) | ELISA, WB, FC, FuncS | Mouse scFv |
| HPAB-2989LY-S(P) | Mouse Anti-CNR1 Recombinant Antibody; scFv Fragment (HPAB-2989LY-S(P)) | ELISA, WB, FC, FuncS | Mouse scFv |
| HPAB-2990LY-S(P) | Mouse Anti-CNR1 Recombinant Antibody; scFv Fragment (HPAB-2990LY-S(P)) | ELISA, WB, FC, FuncS | Mouse scFv |
| HPAB-2991LY-S(P) | Mouse Anti-CNR1 Recombinant Antibody; scFv Fragment (HPAB-2991LY-S(P)) | ELISA, WB, FC, FuncS | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-2987LY-F(E) | Human Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-2987LY-F(E)) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) Fab |
| HPAB-2988LY-F(E) | Human Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-2988LY-F(E)) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) Fab |
| HPAB-2989LY-F(E) | Human Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-2989LY-F(E)) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) Fab |
| HPAB-2990LY-F(E) | Human Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-2990LY-F(E)) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) Fab |
| HPAB-2991LY-F(E) | Human Anti-CNR1 Recombinant Antibody; Fab Fragment (HPAB-2991LY-F(E)) | ELISA, WB, FC, FuncS | Chimeric (mouse/human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC244 | Recombinant Anti-CNR1 Vesicular Antibody, EV Displayed (VS-0425-YC244) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1565 | Anti-CNR1 Immunohistochemistry Kit | IHC |
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