Human Anti-CNR1 scFv-Fc Chimera (VS-0425-FY72) (CAT#: VS-0425-FY72)
CNR1 (Cannabinoid receptor 1) is a G-protein-coupled receptor involved in pain signaling. This scFv-Fc construct is designed for potential use in pain management and neurodegenerative diseases by targeting CNR1.
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Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line AF22
(Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & actin filaments.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42256/1595_A8_2_selected.jpg
(Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & actin filaments.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42256/1595_A8_2_selected.jpg
Figure 2 Low expression in liver
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_7_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_7_4_val_selected.jpg
Figure 3 Cerebral cortex
(Neuropil Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_B_8_5.jpg
(Neuropil Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_B_8_5.jpg
Figure 4 Colon
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_7_3.jpg
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_7_3.jpg
Figure 5 Testis
(Sertoli cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_6_6.jpg
(Sertoli cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_6_6.jpg
Figure 6 RNA cell line category: Group enriched (ASC diff, HSkMC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118432-CNR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118432-CNR1
Specifications
- Immunogen
- The immunogen is HEK293 cells have been transfected to express the proteins PADRE-hCB1 and E3K-hCB1.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human CNR1
- Species Reactivity
- Human
- Applications
- Inhibition, Antagonist
- Related Disease
- Cannabis Dependence and Anxiety
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- In the GTP-Eu assay, the antibody antagonized the endogenous CB1 agonist anandamide with an IC₅₀ value of approximately 10.14 nM.
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Cannabinoid Receptor 1; Cannabinoid Receptor 1 (Brain); CANN6; CB-R; CNR; CB1
- Gene ID
- 1268
- UniProt ID
- P21554
- Long Name
- Cannabinoid Receptor 1
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane, Membrane raft, Mitochondrion outer membrane, Cell projection, axon, Presynapse
- Post Translation Modifications
- Palmitoylation at Cys-415 is important for recruitment at plasma membrane and lipid rafts and association with G protein alpha subunits.
Glycosylation at Asn77 and Asn83
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 2 sites
- Protein Refseq
- XP_047274127.1; XP_047274128.1; XP_047274129.1; XP_054210179.1; XP_054210180.1
- Function
- Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Human Antibody Products
IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1492CL | Human Anti-CNR1 Recombinant Antibody (TAB-1492CL) | FC, FuncS | Human IgG |
| TAB-1492CL-S(P) | Human Anti-CNR1 Recombinant Antibody; scFv Fragment (TAB-1492CL-S(P)) | FC, FuncS | Human scFv |
| TAB-1492CL-F(E) | Human Anti-CNR1 Recombinant Antibody; Fab Fragment (TAB-1492CL-F(E)) | FC, FuncS | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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