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    CNR1

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    For Research Use Only. Not For Clinical Use.


    Background

    CNR1 (Cannabinoid Receptor 1) is a Protein Coding gene. Diseases associated with CNR1 include Cannabis Dependence and Anxiety. Among its related pathways are N-cadherin signaling events and Cell-type Dependent Selectivity of CCK2R Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is CNR2.
    Protein class

    Disease related genes, FDA approved drug targets, G-protein coupled receptors, Transporters

    Predicted location

    Intracellular, Membrane (different isoforms)

    Single cell type specificity

    Cell type enhanced (Inhibitory neurons, Sertoli cells, Excitatory neurons)

    Immune cell specificity

    Not detected in immune cells

    Cell line specificity

    Group enriched (ASC diff, HSkMC)

    Interaction

    Interacts (via C-terminus) with CNRIP1; this interaction attenuates constitutive, but not agonist-dependent, inhibition of voltage-gated Ca(2+) channels in neurons (PubMed:17895407). Associates with G protein alpha subunits, including G(i) alpha-1/GNAI1, G(i) alpha-3/GNAI3 and G(o)-alpha/GNAO1; palmitoylation is important for interaction with GNAI3 and GNAO1 (PubMed:12237474).

    Molecular function

    G-protein coupled receptor, Receptor, Transducer

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