Recombinant Anti-CNR1 Vesicular Antibody, EV Displayed (VS-0425-YC244) (CAT#: VS-0425-YC244)
The Recombinant Anti-CNR1 Vesicular Antibody, EV Displayed (VS-0425-YC244) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CNR1-expressed cells or tissues. The CNR1 is Cannabinoid Receptor 1, part of G-protein coupled receptor activity pathways, associated with Cannabis Dependence.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line AF22
(Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & actin filaments.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42256/1595_A8_2_selected.jpg
(Immunofluorescent staining of human cell line AF22 shows localization to plasma membrane & actin filaments.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/42256/1595_A8_2_selected.jpg
Figure 2 Low expression in liver
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_7_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_7_4_val_selected.jpg
Figure 3 Cerebral cortex
(Neuropil Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_B_8_5.jpg
(Neuropil Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_B_8_5.jpg
Figure 4 Colon
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_7_3.jpg
(Glandular cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_7_3.jpg
Figure 5 Testis
(Sertoli cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_6_6.jpg
(Sertoli cells Staining: High Intensity: Strong Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69945/166905_A_6_6.jpg
Figure 6 RNA cell line category: Group enriched (ASC diff, HSkMC)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118432-CNR1
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000118432-CNR1
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CNR1
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Cannabinoid receptor 1
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Cellular Localization
- Plasma membrane, Actin filaments
- Introduction
- CNR1 (Cannabinoid Receptor 1) is a Protein Coding gene. Diseases associated with CNR1 include Cannabis Dependence and Anxiety. Among its related pathways are N-cadherin signaling events and Cell-type Dependent Selectivity of CCK2R Signaling. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and cannabinoid receptor activity. An important paralog of this gene is CNR2.
- Alternative Names
- CANN6, CB-R, CB1, CB1A, CB1K5, CNR
- Gene ID
- 1268
- UniProt ID
- P21554
Downloads
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Human Antibody Products
IgG Antibody Products
ScFv Antibody Products
Fab Antibody Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1492CL | Human Anti-CNR1 Recombinant Antibody (TAB-1492CL) | FC, FuncS | Human IgG |
| TAB-1492CL-S(P) | Human Anti-CNR1 Recombinant Antibody; scFv Fragment (TAB-1492CL-S(P)) | FC, FuncS | Human scFv |
| TAB-1492CL-F(E) | Human Anti-CNR1 Recombinant Antibody; Fab Fragment (TAB-1492CL-F(E)) | FC, FuncS | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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