Human Anti-DPP4 scFv-Fc Chimera (VS-0425-FY101)
CAT#: VS-0425-FY101
This scFv-Fc construct targets DPP4 (Dipeptidyl peptidase-4), an enzyme involved in the breakdown of incretin hormones and other peptides. By inhibiting DPP4, it can extend the effects of incretins and is being explored for its potential use in diabetes management and other metabolic disorders.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human duodenum
Immunohistochemical staining of human duodenum shows strong membranous positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68778/169922_A_9_2_selected.jpg
Normal Tissue
Figure 2 Parathyroid gland
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71236/169918_A_3_8_selected.jpg
Normal Tissue
Figure 3 Prostate
High expression
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/45970/113236_A_2_5_val_selected.jpg
Normal Tissue
Figure 4 Salivary gland
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71236/169918_B_2_1.jpg
Normal Tissue
Figure 5 Colon
Enterocytes - Microvilli Staining: Medium Intensity: Moderate Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71236/169918_A_9_3.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71236/169918_A_8_4.jpg
Normal Tissue
Figure 7 Kidney
Bowman's capsule Staining: High Intensity: Strong Quantity: 75%-25% Cells in glomeruli Staining: High Intensity: Strong Quantity: 75%-25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/71236/169918_A_8_5.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (ASC diff, ASC TERT1, BJ hTERT+, RPTEC TERT1)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197635-DPP4
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human DPP4
- Species Reactivity
- Human
- Applications
- Western Blot, Dot Blot, ELISA, Inhibition
- Related Disease
- Middle East Respiratory Syndrome and Nasopharyngitis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Western Blot: 2 μg/mL
Dot Blot: 2 μg/mL
ELISA: 0.1 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Dipeptidyl Peptidase 4; Adenosine Deaminase Complexing Protein 2; Dipeptidylpeptidase IV (CD26, Adenosine Deaminase Complexing Protein 2); T-Cell Activation Antigen CD26; Dipeptidyl Peptidase IV; EC 3.4.14.5; DPP IV; ADCP-2; ADCP2
- Gene ID
- 1803
- UniProt ID
- P27487
- Long Name
- Dipeptidyl Peptidase 4
- Sequence Similarities
- Belongs to the peptidase S9B family. DPPIV subfamily.
- Cellular Localization
- Cell membrane; Single-pass type II membrane protein; Apical cell membrane; Single-pass type II membrane protein; Cell projection, invadopodium membrane; Single-pass type II membrane protein; Cell projection, lamellipodium membrane; Single-pass type II membrane protein; Cell junction
- Post Translation Modifications
- The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing.
N- and O-Glycosylated.
Phosphorylated.
Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells.
Mannose 6-phosphorylation is induced during T-cell activation.
Glycosylation at Asn85, Asn92, Asn150, Asn219, Asn229, Asn281, Asn321, Asn520, and Asn685
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect DPP4_HUMAN (1177)
Glycosylation from GlyGen 13 sites, 84 N-linked glycans (5 sites), 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001366533.1; NP_001366534.1; NP_001366535.1; NP_001926.2
- Function
- Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.
Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC.
Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner.
Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion.
In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM.
May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-316 | Mouse Anti-Dpp4 Recombinant Antibody (clone 11A19) | ELISA, WB, FuncS | Mouse IgG |
| PABL-690 | Mouse Anti-Dpp4 Recombinant Antibody (clone MK-0431) | WB, FuncS | Mouse IgG |
| HPAB-0213-YC | Mouse Anti-DPP4 Recombinant Antibody (HPAB-0213-YC) | FC, FuncS | Mouse IgG2b |
| FAMAB-1627CQ | Mouse Anti-DPP4 Recombinant Antibody (clone OX61) | ICC, IP, RIA, WB, FC, IF, IHC | Mouse IgG2a |
| VS13-YC320 | Rabbit Anti-DPP4 Recombinant Antibody (VS13-YC320) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-316 | Mouse Anti-Dpp4 Recombinant Antibody (clone 11A19); scFv Fragment | ELISA, WB, FuncS | Mouse scFv |
| PSBL-683 | Mouse Anti-Dpp4 Recombinant Antibody (clone MK-0431); scFv Fragment | WB, FuncS | Mouse scFv |
| HPAB-0213-YC-S(P) | Mouse Anti-DPP4 Recombinant Antibody; scFv Fragment (HPAB-0213-YC-S(P)) | FC, FuncS | Mouse scFv |
| HPAB-0214-YC-S(P) | Human Anti-DPP4 Recombinant Antibody; scFv Fragment (HPAB-0214-YC-S(P)) | ELISA | Humanized scFv |
| HPAB-3029LY-S(P) | Human Anti-DPP4 Recombinant Antibody; scFv Fragment (HPAB-3029LY-S(P)) | FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-683 | Mouse Anti-DPP4 Recombinant Antibody (clone MK-0431); Fab Fragment | WB, FuncS | Mouse Fab |
| HPAB-0213-YC-F(E) | Mouse Anti-DPP4 Recombinant Antibody; Fab Fragment (HPAB-0213-YC-F(E)) | FC, FuncS | Mouse Fab |
| HPAB-0214-YC-F(E) | Human Anti-DPP4 Recombinant Antibody; Fab Fragment (HPAB-0214-YC-F(E)) | ELISA | Humanized Fab |
| HPAB-0215-YC-F(E) | Human Anti-DPP4 Recombinant Antibody; Fab Fragment (HPAB-0215-YC-F(E)) | ELISA | Humanized Fab |
| HPAB-3029LY-F(E) | Human Anti-DPP4 Recombinant Antibody; Fab Fragment (HPAB-3029LY-F(E)) | FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1041 | Hi-Affi™ Rabbit Anti-DPP4 Recombinant Antibody (clone DS1041AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY98 | CytoStream™ Rat Anti-DPP4 Recombinant Antibody (clone H194-112) | FC | Rat IgG2a, kappa |
| VS-0225-XY99 | CytoStream™ Mouse Anti-DPP4 Recombinant Antibody (VS-0225-XY99) | FC | Mouse IgG1, kappa |
| VS-0225-XY100 | CytoStream™ Mouse Anti-DPP4 Recombinant Antibody (VS-0225-XY100) | FC | Mouse IgG2a, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2067 | Anti-DPP4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2068 | Anti-Mouse DPP4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2069 | Anti-Rat DPP4 Immunohistochemistry Kit | IHC |
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