Human Anti-DPP4 scFv-Fc Chimera (VS-0425-FY101) (CAT#: VS-0425-FY101)

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human DPP4

• Species Reactivity
• Human

• Applications
• Western Blot, Dot Blot, ELISA, Inhibition

• Related Disease
• Middle East Respiratory Syndrome and Nasopharyngitis

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Western Blot: 2 μg/mL
  Dot Blot: 2 μg/mL
  ELISA: 0.1 μg/mL
  The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Dipeptidyl Peptidase 4; Adenosine Deaminase Complexing Protein 2; Dipeptidylpeptidase IV (CD26, Adenosine Deaminase Complexing Protein 2); T-Cell Activation Antigen CD26; Dipeptidyl Peptidase IV; EC 3.4.14.5; DPP IV; ADCP-2; ADCP2

• Gene ID
• 1803

• UniProt ID
• P27487

• Long Name
• Dipeptidyl Peptidase 4

• Sequence Similarities
• Belongs to the peptidase S9B family. DPPIV subfamily.

• Cellular Localization
• Cell membrane; Single-pass type II membrane protein; Apical cell membrane; Single-pass type II membrane protein; Cell projection, invadopodium membrane; Single-pass type II membrane protein; Cell projection, lamellipodium membrane; Single-pass type II membrane protein; Cell junction

• Post Translation Modifications
• The soluble form (Dipeptidyl peptidase 4 soluble form also named SDPP) derives from the membrane form (Dipeptidyl peptidase 4 membrane form also named MDPP) by proteolytic processing.
  N- and O-Glycosylated.
  Phosphorylated.
  Mannose 6-phosphate residues in the carbohydrate moiety are necessary for interaction with IGF2R in activated T-cells.
  Mannose 6-phosphorylation is induced during T-cell activation.
  Glycosylation at Asn85, Asn92, Asn150, Asn219, Asn229, Asn281, Asn321, Asn520, and Asn685
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect DPP4_HUMAN (1177)
  Glycosylation from GlyGen 13 sites, 84 N-linked glycans (5 sites), 1 O-linked glycan (1 site)

• Protein Refseq
• NP_001366533.1; NP_001366534.1; NP_001366535.1; NP_001926.2

• Function
• Cell surface glycoprotein receptor involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation.
  Acts as a positive regulator of T-cell coactivation, by binding at least ADA, CAV1, IGF2R, and PTPRC.
  Its binding to CAV1 and CARD11 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependent manner.
  Its interaction with ADA also regulates lymphocyte-epithelial cell adhesion.
  In association with FAP is involved in the pericellular proteolysis of the extracellular matrix (ECM), the migration and invasion of endothelial cells into the ECM.
  May be involved in the promotion of lymphatic endothelial cells adhesion, migration and tube formation.

Select a product category from the dropdown menu below to view related products.