Human Anti-DSC2 scFv-Fc Chimera (VS-0425-FY20) (CAT#: VS-0425-FY20)

• Immunogen
• Immunized with DSC2 (AA 1-901)-transfected 293T cells.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human DSC2

• Species Reactivity
• Human

• Applications
• ADCC, ELISA

• Related Disease
• Cancer

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Desmocollin 2; Cadherin Family Member 2; CDHF2; DSC3; Desmosomal Glycoprotein II/III; Desmosomal Glycoprotein III; Desmosomal Glycoprotein II

• Gene ID
• 1824

• UniProt ID
• Q02487

• Long Name
• Desmocollin 2

• Cellular Localization
• Cell membrane, Cell junction, Desmosome

• Post Translation Modifications
• Glycosylation at Asn34, Asn166, Asn392, Asn546, Asn629, and Asn675
  Ubiquitination at Lys890
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyConnect DSC2_HUMAN (1171)
  Glycosylation from GlyGen 6 sites, 65 N-linked glycans (5 sites)

• Protein Refseq
• NP_001393435.1; NP_001393436.1; NP_004940.1; NP_077740.1

• Function
• A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion.
  Promotes timely incorporation of DSG2 into desmosome intercellular junctions and promotes interaction of desmosome cell junctions with intermediate filament cytokeratin, via modulation of DSP phosphorylation.
  Plays an important role in desmosome-mediated maintenance of intestinal epithelial cell intercellular adhesion strength and barrier function.
  Positively regulates wound healing of intestinal mucosa via promotion of epithelial cell migration, and also plays a role in mechanotransduction of force between intestinal epithelial cells and extracellular matrix.
  May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
  May promote p38MAPK signaling activation that facilitates keratinocyte migration.

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