Human Anti-EPO scFv-Fc Chimera (VS-0425-FY105)
CAT#: VS-0425-FY105
This scFv-Fc construct targets EPO (Erythropoietin), a hormone that regulates red blood cell production. By binding to EPO, it can modulate erythropoiesis and has potential applications in treating anemia and other conditions related to erythropoietin dysregulation.
Gene Expression
RNA Expression
Figure 1 RNA cell line category: Group enriched (BEWO, Hep G2)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000130427-EPO
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Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human EPO
- Species Reactivity
- Human
- Applications
- ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Erythropoietin; Epoetin; MVCD2; EP
- Gene ID
- 2056
- UniProt ID
- P01588
- Long Name
- Erythropoietin
- Sequence Similarities
- Belongs to the EPO/TPO family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Glycosylation at Asn51, Asn65, Asn110, and Ser153
Modification sites at PhosphoSitePlus
Glycosylation from GlyConnect EPO_HUMAN (140)
Glycosylation from GlyGen 5 sites, 190 N-linked glycans (4 sites), 19 O-linked glycans (2 sites)
- Protein Refseq
- NP_000790.2
- Function
- Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass.
Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3.
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Related Diseases
Asthma
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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|---|---|---|---|
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-326-F(E) | Recombinant Anti-human EPO Antibody Fab Fragment | FC, Neut, Funcs | Fab |
| MHH-326-F(E) | Recombinant Human Anti-human EPO Antibody Fab Fragment | WB, IHC, FuncS | Fab |
| HPAB-AP079-YC-F(E) | Human Anti-EPO Recombinant Antibody; Fab Fragment (HPAB-AP079-YC-F(E)) | ELISA | Human Fab |
| HPAB-AP080-YC-F(E) | Human Anti-EPO Recombinant Antibody; Fab Fragment (HPAB-AP080-YC-F(E)) | ELISA | Human Fab |
| HPAB-AP081-YC-F(E) | Human Anti-EPO Recombinant Antibody; Fab Fragment (HPAB-AP081-YC-F(E)) | ELISA, Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-326-S(P) | Recombinant Anti-human EPO Antibody scFv Fragment | ELISA, WB, IF, FuncS | scFv |
| MHH-326-S(P) | Recombinant Human Anti-human EPO Antibody scFv Fragment | ELISA, WB, FC, FuncS | scFv |
| HPAB-AP079-YC-S(P) | Human Anti-EPO Recombinant Antibody; scFv Fragment (HPAB-AP079-YC-S(P)) | ELISA | Human scFv |
| HPAB-AP080-YC-S(P) | Human Anti-EPO Recombinant Antibody; scFv Fragment (HPAB-AP080-YC-S(P)) | ELISA | Human scFv |
| HPAB-AP081-YC-S(P) | Human Anti-EPO Recombinant Antibody; scFv Fragment (HPAB-AP081-YC-S(P)) | ELISA, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-058 | Recombinant Anti-Chinese hamster Epo VHH Single Domain Antibody | WB, ELISA, IHC, FuncS | Llama VHH |
| NABG-133 | Camelid Anti-human EPO VHH Single Domain Antibody [Biotin] | ELISA, WB, BLI, SPR |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-005WM | Human Anti-EPO Recombinant Antibody (TAB-005WM) | ELISA, Neut | Human antibody |
| TAB-005WM-S(P) | Human Anti-EPO Recombinant Antibody; scFv Fragment (TAB-005WM-S(P)) | ELISA | Human scFv |
| TAB-006WM-S(P) | Human Anti-EPO Recombinant Antibody; scFv Fragment (TAB-006WM-S(P)) | ELISA, Neut | Human scFv |
| TAB-005WM-F(E) | Human Anti-EPO Recombinant Antibody; Fab Fragment (TAB-005WM-F(E)) | ELISA | Human Fab |
| TAB-006WM-F(E) | Human Anti-EPO Recombinant Antibody; Fab Fragment (TAB-006WM-F(E)) | ELISA, Neut | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-729CQ | Mouse Anti-EPO Recombinant Antibody (NEUT-729CQ) | ELISA, Neut, ELISpot | Mouse IgE, κ |
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| NEUT-732CQ | Rat Anti-Epo Recombinant Antibody (clone RM0364-10F3) | ELISA, Neut | Rat IgG2 |
| NEUT-733CQ | Rat Anti-Epo Recombinant Antibody (clone CBL884) | Neut | Rat IgG2 |
| NEUT-734CQ | Rat Anti-Epo Recombinant Antibody (clone CBL557) | ELISA, Neut | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS3-QX377 | Mouse Anti-EPO Recombinant Antibody (clone 511CT20.2.4) | WB | Mouse IgM |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2328 | Anti-EPO Immunohistochemistry Kit | IHC | |
| VS-0525-XY2329 | Anti-Human EPO Immunohistochemistry Kit | IHC |
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