Recombinant Human Anti-gp100 Soluble TCR (clone 296/107) (C-Cys)
CAT#: VS-0622-YF4499
Human TCR (clone 296/107) recognizes gp100 peptide (YLEPGPVTL) in the context of HLA-A*02:01. Soluble TCR is expressed with C-terminal Cys strategy (TRAV-TRAC partial-Cys, TRBV-TRBC partial-Cys). Depending the C-terminal Cys, two chains form heterodimer. Please note that the activity is not guaranteed.
Specifications
- Host Species
- Human
- Target
- gp100
- Epitope
- YLEPGPVTL
- MHC
- HLA-A*02:01
- Clone
- clone 296/107
- Type
- Soluble TCR (C-Cys)
- Related Disease
- Melanoma
- TCR Expression Strategy
- C-Cys strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on C-terminal Cys. The soluble TCR contains variable regions and partial constant regions.
Target
- Alternative Names
- YLE-8A; YLEPGPVTL
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Stable and Effective Design
The C-Cys strategy used in this product provides robust stability, ensuring reliable interactions with the gp100 peptide. Its design facilitated more accurate studies into melanoma-related immune responses, contributing valuable information to our ongoing cancer research.
Target-Specific Precision
Using this TCR has enhanced our understanding of gp100 in melanoma, offering target-specific precision that is critical for therapeutic development. Its role in facilitating robust immune response studies has been central to the success of our research initiatives.
Q&As
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How does the C-Cys strategy benefit this TCR?
A: The C-Cys strategy promotes the formation of stable heterodimers using C-terminal cysteine residues, enhancing the structural integrity and binding efficiency of the TCR to its target antigen, gp100.
-
What advantages does using this TCR provide in melanoma studies?
A: This TCR facilitates detailed analysis of antigen-specific T-cell responses against melanoma, aiding researchers in understanding immune evasion mechanisms and potentially developing targeted immunotherapies.
View the frequently asked questions answered by Creative Biolabs Support.
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