Human Anti-IL12 (clone Y61) scFv-Fc Chimera (CAT#: VS-0425-FY123)
Anti-IL12 scFv-Fc is a recombinant antibody targeting the heterodimeric Interleukin-12 (IL-12) cytokine, composed of the p35 (IL12A) and p40 (IL12B) subunits. The scFv provides specific binding to the intact IL-12 molecule, while the Fc region enhances stability and potential for dimerization. This format is being developed to block the complete IL-12 signaling pathway, aiming to modulate Th1 immune responses in autoimmune diseases, inflammatory conditions, and potentially cancer.
Specific Inquiry
Custom Production
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
We require custom production
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL12
- Species Reactivity
- Human
- Clone
- Y61
- Applications
- Neutralization
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- IL12; interleukin 12A and interleukin 12B; P35; CLMF; NFSK; NKSF1; IL-12A and CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B
- Long Name
- interleukin 12A and interleukin 12B
- Function
- The IL12 gene family encodes for interleukin-12 (IL-12), a heterodimeric cytokine crucial for bridging innate and adaptive immunity. The active IL-12 protein is composed of two subunits, p35 (encoded by IL12A) and p40 (encoded by IL12B).
The primary function of IL-12 is to stimulate the differentiation of naive CD4+ T cells into Th1 cells. It also enhances the cytotoxic activity of natural killer (NK) cells and CD8+ T cells, promoting the production of interferon-gamma (IFN-γ). By inducing a Th1-biased immune response, IL-12 plays a vital role in host defense against intracellular pathogens and tumors. Its dysregulation, however, can contribute to inflammatory and autoimmune diseases.
Related Resources
Asthma
Inflammatory Bowel Diseases
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "Clone Y61"
See other products for "IL12"
Select a product category from the dropdown menu below to view related products.
Please select product type
IgG Antibody Products
Fab Antibody Products
ScFv Antibody Products
Blocking Antibody Products
Neutralizing Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABL-602 | Human Anti-IL12 Recombinant Antibody (clone CNTO1275) | Neut, ELISA | Humanized IgG |
| HPAB-1551WJ | Human Anti-IL12 Recombinant Antibody (clone 70-1) | ELISA, WB | Human IgG1 |
| HPAB-1552WJ | Human Anti-IL12 Recombinant Antibody (clone 101-11) | ELISA, WB | Human IgG1 |
| HPAB-1554WJ | Human Anti-IL12 Recombinant Antibody (clone 78-34) | ELISA, WB | Human IgG1 |
| HPAB-1585WJ | Human Anti-IL12 Recombinant Antibody (clone J695) | ELISA, WB | Human IgG |
Customer Reviews and Q&As
There are currently no Customer reviews or questions for VS-0425-FY123. Click the button above to contact us or submit your feedback about this product.
Popular products with customers
Application: IF, IP, Neut, FuncS, ELISA, FC, ICC
Application: FuncS, IF, Neut, ELISA, FC, IP, IHC
Application: IP, IF, FuncS, FC, Neut, ELISA, ICC
Application: IP, IF, FuncS, FC, Neut, ELISA, IHC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
-YJ-1.jpg)
Application: ELISA
Application: ELISA, FC, WB, Block
Application: Neut, ELISA, FuncS
Application: ELISA, FuncS, Neut, IF, WB, EM, Inhib, IHC
For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
