Human Anti-IL12 (clone Y61) scFv-Fc Chimera
CAT#: VS-0425-FY123
Anti-IL12 scFv-Fc is a recombinant antibody targeting the heterodimeric Interleukin-12 (IL-12) cytokine, composed of the p35 (IL12A) and p40 (IL12B) subunits. The scFv provides specific binding to the intact IL-12 molecule, while the Fc region enhances stability and potential for dimerization. This format is being developed to block the complete IL-12 signaling pathway, aiming to modulate Th1 immune responses in autoimmune diseases, inflammatory conditions, and potentially cancer.
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human IL12
- Species Reactivity
- Human
- Clone
- Y61
- Applications
- Neutralization
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- IL12; interleukin 12A and interleukin 12B; P35; CLMF; NFSK; NKSF1; IL-12A and CLMF; NKSF; CLMF2; IMD28; IMD29; NKSF2; IL-12B
- Long Name
- interleukin 12A and interleukin 12B
- Function
- The IL12 gene family encodes for interleukin-12 (IL-12), a heterodimeric cytokine crucial for bridging innate and adaptive immunity. The active IL-12 protein is composed of two subunits, p35 (encoded by IL12A) and p40 (encoded by IL12B).
The primary function of IL-12 is to stimulate the differentiation of naive CD4+ T cells into Th1 cells. It also enhances the cytotoxic activity of natural killer (NK) cells and CD8+ T cells, promoting the production of interferon-gamma (IFN-γ). By inducing a Th1-biased immune response, IL-12 plays a vital role in host defense against intracellular pathogens and tumors. Its dysregulation, however, can contribute to inflammatory and autoimmune diseases.
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Related Diseases
Asthma
Inflammatory Bowel Diseases
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-597 | Human Anti-IL12 Recombinant Antibody (clone CNTO1275); scFv Fragment | Neut, ELISA | Humanized scFv |
| HPAB-0844-FY-F(E) | Human Anti-IL12 Recombinant Antibody (clone Y61); scFv Fragment | Neut | Human scFv |
| HPAB-1551WJ-S(P) | Human Anti-IL12 Recombinant Antibody; scFv Fragment (clone 70-1) | ELISA, WB | Human scFv |
| HPAB-1552WJ-S(P) | Human Anti-IL12 Recombinant Antibody; scFv Fragment (clone 101-11) | ELISA, WB | Human scFv |
| HPAB-1554WJ-S(P) | Human Anti-IL12 Recombinant Antibody; scFv Fragment (clone 78-34) | ELISA, WB | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1151CQ | Rat Anti-IL12 Recombinant Antibody (clone 20C2) | Block, ELISA, WB | Rat IgG1 |
| NEUT-1153CQ | Rat Anti-IL12 Recombinant Antibody (clone C8.6) | Block, ELISA, WB | Rat IgG1 |
| NEUT-1162CQ | Mouse Anti-IL12 Recombinant Antibody (clone B-T21) | ELISA, Block | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1152CQ | Mouse Anti-IL12 Recombinant Antibody (clone 31H23) | Neut, WB | Mouse IgG1 |
| NEUT-1154CQ | Mouse Anti-IL12 Recombinant Antibody (clone CBL092) | Neut, WB, IHC | Mouse IgG1 |
| NEUT-1155CQ | Mouse Anti-IL12 Recombinant Antibody (clone CBL244) | ELISA, Neut | Mouse IgG1 |
| NEUT-1156CQ | Rat Anti-IL12 Recombinant Antibody (clone 9A5) | Block, ELISA, ICC, IF, IHC, IP, WB | Rat IgG2b |
| NEUT-1157CQ | Rat Anti-Il12 Recombinant Antibody (NEUT-1157CQ) | WB, IP, Neut, FC | Rat IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-016CQ | Mouse Anti-IL12 Recombinant Antibody (clone YC123) | ELISA, FC, FuncS, ELISAPOT | Mouse IgG1 |
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| HPAB-1552WJ | Human Anti-IL12 Recombinant Antibody (clone 101-11) | ELISA, WB | Human IgG1 |
| HPAB-1554WJ | Human Anti-IL12 Recombinant Antibody (clone 78-34) | ELISA, WB | Human IgG1 |
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