Human Anti-MAG scFv-Fc Chimera (VS-0425-FY155) (CAT#: VS-0425-FY155)
The anti-MAG (myelin-associated glycoprotein) scFv-FC is a specialized recombinant protein that consists of a single-chain variable fragment specific to MAG fused with an FC region. MAG is a critical component in the central nervous system associated with myelin sheath formation and stability. This scFv-FC is used in research and therapeutic contexts, particularly in demyelinating diseases such as multiple sclerosis, aiming to enhance remyelination or inhibit the binding of inhibitory factors that prevent nerve repair.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 Cerebral cortex
(Neuropil
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9345/26620_B_9_5.jpg
(Neuropil
Staining:
High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/
membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/9345/26620_B_9_5.jpg
Figure 2 RNA cell line category: Cell line enriched (WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105695-MAG
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105695-MAG
Figure 2 RNA cell line category: Cell line enriched (WM-115)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105695-MAG
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105695-MAG
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human MAG
- Species Reactivity
- Human
- Applications
- Blocking
- Related Disease
- CNS trauma, Stroke
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Myelin Associated Glycoprotein; Sialic Acid Binding Ig-Like Lectin 4A; SIGLEC-4A; GMA; Sialic Acid-Binding Immunoglobulin-Like Lectin 4A; Myelin-Associated Glycoprotein; SIGLEC4A; S-MAG; SPG75
- Gene ID
- 4099
- UniProt ID
- P20916
- Long Name
- Myelin Associated Glycoprotein
- Sequence Similarities
- Belongs to the immunoglobulin superfamily
- Cellular Localization
- Cell membrane, Membrane raft
- Post Translation Modifications
- N-glycosylated.
Phosphorylated on tyrosine residues.
Ubiquitinated, leading to proteasomal degradation.
Glycosylation at Asn99, Asn106, Asn223, Asn246, Asn315, Asn406, Asn450, and Asn454
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 9 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- NP_001186145.1; NP_002352.1; NP_542167.1
- Function
- Inhibits axon longitudinal growth.
Inhibits axon outgrowth by binding to RTN4R.
Preferentially binds to alpha-2,3-linked sialic acid.
Binds ganglioside Gt1b.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1161z | Mouse Anti-MAG Recombinant Antibody (clone 32F9) | WB, IP, IF, IHC, ELISA | Mouse IgG2a, κ |
| HPAB-0032-LS | Human Anti-MAG Recombinant Antibody | ELISA | Chimeric (mouse/human) IgG1, κ |
| HPAB-J0175-YC | Mouse Anti-MAG Recombinant Antibody (clone muAP022/YC) | ELISA | Mouse IgG |
| HPAB-J0176-YC | Human Anti-MAG Recombinant Antibody (clone chAP022/YC) | ELISA | Chimeric (mouse/human) IgG1 |
| HPAB-J0177-YC | Human Anti-MAG Recombinant Antibody (clone BVh3/CVI3) | ELISA, FuncS | Humanized (mouse/human) IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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