Human Anti-NCR1 scFv-Fc Chimera (VS-0325-FY34) (CAT#: VS-0325-FY34)
Anti-NCR1 scFv-Fc antibody is engineered to specifically target the NCR1 receptor, which is involved in immune responses against tumors and viral infections. Its unique design combines the advantages of single-chain variable fragments (scFv) and Fc domains to enhance stability and efficacy in therapeutic applications. This antibody is primarily utilized in research and potential clinical applications, including cancer immunotherapy and enhancing natural killer (NK) cell activity.
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Subcellular Location
Figure 1 IF staining of human cell line CACO-2
(Immunofluorescent staining of human cell line CACO-2 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49311/1524_G9_2_selected.jpg
(Immunofluorescent staining of human cell line CACO-2 shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/49311/1524_G9_2_selected.jpg
Specifications
- Immunogen
- Recombinant NKp46 extracellular region His-tagged fusion protein (NKp46-His).
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human NCR1
- Species Reactivity
- Human
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- Natural Cytotoxicity Triggering Receptor 1; Natural Killer Cell P46-Related Protein; NK Cell-Activating Receptor; NK-P46; NKP46; LY94; Lymphocyte Antigen 94 (Mouse) Homolog (Activating NK-Receptor; NK-P46)
- Gene ID
- 9437
- UniProt ID
- O76036
- Long Name
- Natural Cytotoxicity Triggering Receptor 1
- Sequence Similarities
- Belongs to the natural cytotoxicity receptor (NCR) family.
- Cellular Localization
- Cell membrane
- Post Translation Modifications
- N-glycosylated.
O-glycosylated.
Glycosylation at Asn216
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site
- Protein Refseq
- XP_011525831.1; XP_011525832.1; XP_047295683.1; XP_054178665.1; XP_054178666.1
- Function
- NCR1 (Natural Cytotoxicity Triggering Receptor 1), also known as NKp46, is a key activating receptor expressed on natural killer (NK) cells. It plays a crucial role in the innate immune system by mediating the recognition and killing of virus-infected and tumor cells. NCR1 recognizes viral and tumor-associated ligands, triggering NK cell activation and cytotoxic responses. Therefore it is a integral part of natural killer cell immunosurveillance.
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Isotype Control
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3142z | Mouse Anti-NCR1 Recombinant Antibody (clone 37H3) | WB, FC, IHC, IHC | Mouse IgG2 |
| FN-126CQ | Recombinant Mouse Anti-NCR1 Antibody (9E2) | Activ, FuncS | Mouse IgG1 |
| FN-162CQ | Recombinant Rat Anti-NCR1 Antibody (CBL-1323) | FC, FuncS | Rat IgG2a, κ |
| MOB-077YJL | Rat Anti-NCR1 Recombinant Antibody (clone 29A1.4) | ELISA, FC | Rat IgG2a |
| VS11-QX116 | Human Anti-NCR1 Recombinant Antibody (clone Bab281) | FC, IP, IF | Human IgG1, κ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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