Recombinant Human Anti-Rac-1 Soluble TCR (C-Cys) (VS-0622-YF3076)

Name: Recombinant Human Anti-Rac-1 Soluble TCR (C-Cys) (VS-0622-YF3076)
SKU: VS-0622-YF3076
Rating: 5 (1 reviews)

CAT#: VS-0622-YF3076

Human TCR recognizes Rac-1 peptide (FSGEHPTV) in the context of HLA-A201. Soluble TCR is expressed with C-terminal Cys strategy (TRAV-TRAC partial-Cys, TRBV-TRBC partial-Cys). Depending the C-terminal Cys, two chains form heterodimer. Please note that the activity is not guaranteed.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm & cytosol.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35994/265_F2_2_selected.jpg

Normal Tissue Figure 2 IHC staining of human duodenum

Immunohistochemical staining of human duodenum shows moderate cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35994/ihc_selected.jpg

Normal Tissue Figure 3 Kidney

Cells in glomeruli Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47820/112664_A_8_5.jpg

Normal Tissue Figure 4 Testis

Leydig cells Staining: Low Intensity: Moderate Quantity: <25% Spermatogonia cells Staining: Low Intensity: Moderate

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47820/112664_A_5_6.jpg

Normal Tissue Figure 5 Colon

Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47820/112664_A_9_3.jpg

Normal Tissue Figure 6 Lymph node

Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47820/112664_A_9_8.jpg

Normal Tissue Figure 7 Skin

Keratinocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Melanocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/47820/112664_B_9_1.jpg

RNA Expression Figure 8 RNA cell line category: Low cell line specificity

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000136238-RAC1

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Specifications

Host Species
Human

Target
Rac-1

Species Reactivity
Human

Epitope
FSGEHPTV

MHC
HLA-A201

Type
Soluble TCR (C-Cys)

Related Disease
Melanoma

TCR Expression Strategy
C-Cys strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on C-terminal Cys. The soluble TCR contains variable regions and partial constant regions.

Target

Alternative Names
MIG5; Rac-1; TC-25; p21-Rac1

Gene ID
5879

UniProt ID
P63000

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Related Signaling Pathways

Canonical Wnt Signaling Pathway

MAPK Signaling Pathway

Non-Canonical Wnt Signaling Pathway

Downloadable Resources

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Datasheet

Datasheet - VS-0622-YF3076.pdf

MSDS

MSDS - VS-0622-YF3076.pdf

COA

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