Mouse Anti-RAC1 Recombinant Antibody (VS3-FY2857) (CAT#: VS3-FY2857)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human, Mouse and Rat RAC1

• Species Reactivity
• Human, Mouse, Rat

• Applications
• Western Blot, Immunohistochemistry, Flow cytometry

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 21.5 kDa.

• Related Disease
• Intellectual Developmental Disorder, Autosomal Dominant 48 and Microcephaly-Corpus Callosum And Cerebellar Vermis Hypoplasia-Facial Dysmorphism-Intellectual Disability Syndrom

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/1000
  Immunohistochemistry: 1/50-1/200
  Flow cytometry: 1/50-1/100

• Alternative Names
• Rac Family Small GTPase 1; Ras-Related C3 Botulinum Toxin Substrate 1 (Rho Family, Small GTP Binding Protein Rac1); Cell Migration-Inducing Gene 5 Protein; Ras-Like Protein TC25; P21-Rac1; Ras-Related C3 Botulinum Toxin Substrate 1

• Gene ID
• 5879

• UniProt ID
• P63000

• Sequence Similarities
• Belongs to the small GTPase superfamily. Rho family.

• Cellular Localization
• Cell membrane
  Lipid-anchor
  Cytoplasmic side
  Melanosome
  Cytoplasm
  Cell projection, lamellipodium
  Cell projection, dendrite

• Post Translation Modifications
• GTP-bound active form is ubiquitinated by HACE1, leading to its degradation by the proteasome. (P63000-RAC1_HUMAN)
  Phosphorylated by AKT at Ser-71. (P63000-RAC1_HUMAN)
  Ubiquitinated at Lys-166 in a FBXL19-mediated manner; leading to proteasomal degradation. (P63000-RAC1_HUMAN)
  (Microbial infection) AMPylation at Tyr-32 and Thr-35 are mediated by bacterial enzymes in case of infection by H.somnus and V.parahaemolyticus, respectively

• Protein Refseq
• NP_061485.1

• Function
• Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states.
  In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization, neurons adhesion, migration and differentiation, and growth-factor induced formation of membrane ruffles.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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