Human Anti-VSIG4 scFv-Fc Chimera (VS-0325-FY42) (CAT#: VS-0325-FY42)
The anti-VSIG4 scFv-Fc antibody targets V-set and Immunoglobulin domain-containing protein 4 (VSIG4), a protein involved in immune regulation. It is designed to modulate VSIG4 function, which may have therapeutic implications in autoimmune and inflammatory diseases.
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Subcellular Location
Normal Tissue
Figure 1 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3903/if_selected.jpg
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane & cytosol.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3903/if_selected.jpg
Figure 2 Lung
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3903/12486_A_3_4_selected.jpg
(High expression)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/3903/12486_A_3_4_selected.jpg
Figure 3 Lymph node
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26000/55640_A_9_8.jpg
(Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/26000/55640_A_9_8.jpg
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human VSIG4
- Species Reactivity
- Human
- Applications
- Neutralization, ELISA, Flow Cytometry
- Related Disease
- Autoimmune and inflammatory disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Target
- Alternative Names
- V-Set And Immunoglobulin Domain Containing 4; Protein Z39Ig; Z39IG; CRIg; Complement Receptor Of The Immunoglobulin Superfamily; V-Set And Immunoglobulin Domain-Containing Protein 4; Ig Superfamily Protein
- Gene ID
- 11326
- UniProt ID
- Q9Y279
- Long Name
- V-Set And Immunoglobulin Domain Containing 4
- Cellular Localization
- Membrane
- Protein Refseq
- NP_001093901.1; NP_001171759.1; NP_001171760.1
- Function
- This gene encodes a v-set and immunoglobulin-domain containing protein that is structurally related to the B7 family of immune regulatory proteins. The encoded protein may be a negative regulator of T-cell responses. This protein is also a receptor for the complement component 3 fragments C3b and iC3b. Alternate splicing results in multiple transcript variants.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2062z | Mouse Anti-VSIG4 Recombinant Antibody (MOB-2062z) | ELISA, WB, IP, IF, IHC, FC | Mouse IgG1, κ |
| VS4-CJ155 | Recombinant Human Anti-VSIG4 Antibody (clone 12D12) | ELISA | Human IgG1 |
| VS-0723-WK183 | Human Anti-VSIG4 Recombinant Antibody (VS-0723-WK183) | FC | Chimeric (rabbit/human) IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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