Mouse Anti-AML scFv-Fc Chimera (VS-0125-FY111)
CAT#: VS-0125-FY111
The antibody product is a recombinant scFv-Fc antibody, which is a fusion antibody that combines a specific scFv region highly specific to acute myeloid leukemia (AML) cells. By fusing the scFv region with the Fc fragment of the IgG2a mouse antibody, this antibody is able not only to target and bind to AML cells but also to extend its half-life in vivo, thereby improving therapeutic efficacy. Additionally, the design of this structure enhances the cellular immune activity of the antibody, which may help to more effectively recruit and activate the immune system against tumor cells.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG2a, scFv-Fc
- Species Reactivity
- Human
- Applications
- Bioimaging
- Related Disease
- Acute myeloid leukemia (AML)
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- scFv-Fc antibodies have multiple important functions, primarily including specific binding, internalization, and serving as candidates for immunoconjugates. They are capable of specifically binding to acute myeloid leukemia (AML) cells, which imparts potential value for both diagnosis and treatment. Furthermore, these antibodies can be internalized by AML blast cells, allowing for accurate targeting of the cells and potentially serving as drug delivery vectors. By conjugating with drugs or probes, scFv-Fc antibodies can become crucial tools for targeted therapy and imaging, further enhancing the efficacy and precision of treatments.
Target
- Alternative Names
- Acute Myeloid Leukemia; AML
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
See other products for "AML"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-60 | Recombinant Anti-human AML Antibody | WB, Dot, FuncS | IgG |
| MHH-60 | Recombinant Human Anti-human AML Antibody | ELISA, WB, FuncS | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-60-F(E) | Recombinant Anti-human AML Antibody Fab Fragment | Neut, WB, FuncS | Fab |
| MHH-60-F(E) | Recombinant Human Anti-human AML Antibody Fab Fragment | WB, FC, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-60-S(P) | Recombinant Anti-human AML Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
| MHH-60-S(P) | Recombinant Human Anti-human AML Antibody scFv Fragment | Neut, IF, FuncS | scFv |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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