Mouse Anti-CCL17 scFv-Fc Chimera (VS-0425-FY13) (CAT#: VS-0425-FY13)

• Immunogen
• Human CCL17 protein.

• Host Species
• Mouse

• Type
• Mouse IgG1, scFv-Fc

• Specificity
• The clone is an antibody that specifically binds to human CCL17. It also shows cross-reactivity to cyno (cynomolgus monkey) CCL17. It does not bind to cyno CCL22.

• Species Reactivity
• Human, Cynomolgus monkey

• Applications
• Inhibition, ELISA

• Related Disease
• Eosinophilic Pneumonia and Paragonimiasis

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• Inhibition: 0.5 μg/mL
  The optimal dilution concentration is determined by the experiment.

• Alternative Names
• C-C Motif Chemokine Ligand 17; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 17; Thymus And Activation-Regulated Chemokine; Chemokine (C-C Motif) Ligand 17; Small-Inducible Cytokine A17; CC Chemokine TARC; SCYA17

• Gene ID
• 6361

• UniProt ID
• Q92583

• Long Name
• C-C Motif Chemokine Ligand 17

• Sequence Similarities
• Belongs to the intercrine beta (chemokine CC) family.

• Cellular Localization
• Secreted

• Post Translation Modifications
• Modification sites at PhosphoSitePlus
  Modification sites at neXtProt

• Protein Refseq
• XP_011521558.1; XP_016879019.1; XP_047290404.1; XP_054169572.1; XP_054169573.1

• Function
• Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes.
  Therefore plays an important role in a wide range of inflammatory and immunological processes.
  Acts by binding to CCR4 at T-cell surface.
  Mediates GM-CSF/CSF2-driven pain and inflammation.
  In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions.
  May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation.
  Plays a role in wound healing, mainly by inducing fibroblast migration into the wound.

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