Mouse Anti-CCL17 scFv-Fc Chimera (VS-0425-FY13)
CAT#: VS-0425-FY13
The anti-CCL17 scFv-Fc, on the other hand, is designed to inhibit the activity of CCL17, a chemokine involved in the recruitment of inflammatory cells, making it a valuable tool in managing allergic reactions and autoimmune disorders. Both products are produced using advanced biotechnology methods to ensure high purity and functionality. Their unique mechanisms of action provide promising opportunities for research and clinical applications in immunotherapy. Together, these scFv-Fc products represent significant advancements in targeted therapeutic strategies for various immune-related conditions.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 Stomach
Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2583/6888_A_3_1.jpg
Subcellular Location and Protein Expression
Figure 2 Kidney
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2583/6888_A_9_5.jpg
Subcellular Location and Protein Expression
Figure 3 Testis
Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2583/6888_A_5_6.jpg
Normal Tissue
Figure 4 Lymph node
Germinal center cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/2583/6888_A_7_8.jpg
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Specifications
- Immunogen
- Human CCL17 protein.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- The clone is an antibody that specifically binds to human CCL17. It also shows cross-reactivity to cyno (cynomolgus monkey) CCL17. It does not bind to cyno CCL22.
- Species Reactivity
- Human, Cynomolgus monkey
- Applications
- Inhibition, ELISA
- Related Disease
- Eosinophilic Pneumonia and Paragonimiasis
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Inhibition: 0.5 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- C-C Motif Chemokine Ligand 17; Small Inducible Cytokine Subfamily A (Cys-Cys), Member 17; Thymus And Activation-Regulated Chemokine; Chemokine (C-C Motif) Ligand 17; Small-Inducible Cytokine A17; CC Chemokine TARC; SCYA17
- Gene ID
- 6361
- UniProt ID
- Q92583
- Long Name
- C-C Motif Chemokine Ligand 17
- Sequence Similarities
- Belongs to the intercrine beta (chemokine CC) family.
- Cellular Localization
- Secreted
- Post Translation Modifications
- Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- XP_011521558.1; XP_016879019.1; XP_047290404.1; XP_054169572.1; XP_054169573.1
- Function
- Chemokine, which displays chemotactic activity for T lymphocytes, preferentially Th2 cells, but not monocytes or granulocytes.
Therefore plays an important role in a wide range of inflammatory and immunological processes.
Acts by binding to CCR4 at T-cell surface.
Mediates GM-CSF/CSF2-driven pain and inflammation.
In the brain, required to maintain the typical, highly branched morphology of hippocampal microglia under homeostatic conditions.
May be important for the appropriate adaptation of microglial morphology and synaptic plasticity to acute lipopolysaccharide (LPS)-induced neuroinflammation.
Plays a role in wound healing, mainly by inducing fibroblast migration into the wound.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CCL17"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| NAB-370-VHH | Recombinant Anti-Human CCL17 VHH Single Domain Antibody | WB, ICC, ChiP, FA, ELISA | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2680z | Mouse Anti-CCL17 Recombinant Antibody (clone 25D12) | WB, ELISA, FC | Mouse IgG1, κ |
| HPAB-3117LY | Mouse Anti-CCL17 Recombinant Antibody (HPAB-3117LY) | ELISA | Mouse IgG |
| HPAB-3118LY | Mouse Anti-CCL17 Recombinant Antibody (HPAB-3118LY) | ELISA | Mouse IgG |
| HPAB-3119LY | Mouse Anti-CCL17 Recombinant Antibody (HPAB-3119LY) | ELISA | Mouse IgG |
| HPAB-3120LY | Mouse Anti-CCL17 Recombinant Antibody (HPAB-3120LY) | ELISA | Mouse IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-138CQ | Mouse Anti-CCL17 Recombinant Antibody (clone CBL476) | ELISA(Cap), Neut | Mouse IgG1 |
| NEUT-139CQ | Rat Anti-CCL17 Recombinant Antibody (clone CBL187) | Neut, WB | Rat IgG2 |
| NEUT-140CQ | Rat Anti-CCL17 Recombinant Antibody (clone CBL681) | ELISA(Cap), Neut | Rat IgG2a |
| NEUT-141CQ | Rat Anti-CCL17 Recombinant Antibody (clone RM0170-9K49) | WB, Neut | Rat IgG2 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-4542 | Hi-Affi™ Rabbit Anti-CCL17 Recombinant Antibody (clone TH51DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-3117LY-S(P) | Mouse Anti-CCL17 Recombinant Antibody; scFv Fragment (HPAB-3117LY-S(P)) | ELISA | Mouse scFv |
| HPAB-3118LY-S(P) | Mouse Anti-CCL17 Recombinant Antibody; scFv Fragment (HPAB-3118LY-S(P)) | ELISA | Mouse scFv |
| HPAB-3119LY-S(P) | Mouse Anti-CCL17 Recombinant Antibody; scFv Fragment (HPAB-3119LY-S(P)) | ELISA | Mouse scFv |
| HPAB-3120LY-S(P) | Mouse Anti-CCL17 Recombinant Antibody; scFv Fragment (HPAB-3120LY-S(P)) | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-3117LY-F(E) | Mouse Anti-CCL17 Recombinant Antibody; Fab Fragment (HPAB-3117LY-F(E)) | ELISA | Mouse Fab |
| HPAB-3118LY-F(E) | Mouse Anti-CCL17 Recombinant Antibody; Fab Fragment (HPAB-3118LY-F(E)) | ELISA | Mouse Fab |
| HPAB-3119LY-F(E) | Mouse Anti-CCL17 Recombinant Antibody; Fab Fragment (HPAB-3119LY-F(E)) | ELISA | Mouse Fab |
| HPAB-3120LY-F(E) | Mouse Anti-CCL17 Recombinant Antibody; Fab Fragment (HPAB-3120LY-F(E)) | ELISA | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-YC44 | Recombinant Anti-CCL17 Eliminating Antibody, pH-Sensitive (VS-0625-YC44) | Antigen-Sweeping In Vivo. | Mouse IgG |
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