Mouse Anti-GRIN2B Recombinant Antibody (clone 2) (CAT#: VS-0824-CJ15)
This monoclonal antibody (clone 2) is specifically binding to the GluN1-GluN2B NMDA receptor (NMDAR), recognizing the amino terminal domain (ATD) of the GluN2B subunit. It shows little or no effect on other NMDA receptor subtypes (GluN1B-GluN2A, GluN1B-GluN2C, and GluN1B-GluN2D). This antibody was derived from a mouse immunized with the NMDAR.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 IHC staining of human cerebellum
(Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/ihc_selected.jpg
(Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/ihc_selected.jpg
Figure 2 Cerebral cortex
(Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/154297_B_9_5.jpg
(Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/154297_B_9_5.jpg
Figure 3 Cerebellum
(Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/154297_B_7_8.jpg
(Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/154297_B_7_8.jpg
Figure 4 RNA cell line category: Cell line enhanced (CACO-2, NTERA-2, RPTEC TERT1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000273079-GRIN2B
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000273079-GRIN2B
Specifications
- Immunogen
- Purified intact rat GluN1a-GluN2B NMDAR
- Host Species
- Mouse
- Derivation
- Hybridoma
- Type
- Mouse IgG
- Specificity
- Human, Rat NMDAR
- Species Reactivity
- Human, Rat
- Clone
- 2
- Applications
- Inhib
- Conjugate
- Unconjugated
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody (clone 2) inhibits the activity of GluN1B-GluN2B NMDAR in a concentration-dependent manner.
Target
Recommended Products
Isotype Control
Secondary Antibody
Recommended Dilution Buffer
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
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Non-Human Primate (NHP) Antibody Products
ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1835z | Mouse Anti-GRIN2B Recombinant Antibody (clone 37D8) | WB, ICC, IHC, IP | Mouse IgG2b |
| MOB-2170MZ | Recombinant Mouse Anti-Human GRIN2B Antibody (clone 24B22) | ICC, IHC-G, WB | Mouse antibody |
| FAMAB-1390CQ | Mouse Anti-Grin2b Recombinant Antibody (clone 17) | ELISA | Mouse IgG1 |
| VS-0522-LC194 | Mouse Anti-GRIN2B Recombinant Antibody (VS-0522-LC194) | ICC, IP, KO/KD-WB, WB, IF, IHC | Mouse IgG2a |
| VS-0522-LC195 | Rat Anti-GRIN2B Recombinant Antibody (VS-0522-LC195) | ICC, IP, KO/KD-WB, WB, IF, IHC | Rat IgG2b |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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