Mouse Anti-GRIN2B Recombinant Antibody (clone 2)
CAT#: VS-0824-CJ15
This monoclonal antibody (clone 2) is specifically binding to the GluN1-GluN2B NMDA receptor (NMDAR), recognizing the amino terminal domain (ATD) of the GluN2B subunit. It shows little or no effect on other NMDA receptor subtypes (GluN1B-GluN2A, GluN1B-GluN2C, and GluN1B-GluN2D). This antibody was derived from a mouse immunized with the NMDAR.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human cerebellum
Immunohistochemical staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/154297_B_9_5.jpg
Normal Tissue
Figure 3 Cerebellum
Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/69762/154297_B_7_8.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (CACO-2, NTERA-2, RPTEC TERT1)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000273079-GRIN2B
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Specifications
- Immunogen
- Purified intact rat GluN1a-GluN2B NMDAR
- Host Species
- Mouse
- Derivation
- Hybridoma
- Type
- Mouse IgG
- Antibody Isotype
- IgG2
- Specificity
- Human, Rat NMDAR
- Species Reactivity
- Human, Rat
- Clone
- 2
- Applications
- Inhib
- Conjugate
- Unconjugated
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- This antibody (clone 2) inhibits the activity of GluN1B-GluN2B NMDAR in a concentration-dependent manner.
Target
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
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Recommended Dilution Buffer
- CAT
- Product Name
See other products for "GRIN2B"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1835z | Mouse Anti-GRIN2B Recombinant Antibody (clone 37D8) | WB, ICC, IHC, IP | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2170MZ | Recombinant Mouse Anti-Human GRIN2B Antibody (clone 24B22) | ICC, IHC-G, WB | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1512 | Rabbit Anti-GRIN2B Recombinant Antibody (clone DS1512AB) | FC, WB, ICC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-1390CQ | Mouse Anti-Grin2b Recombinant Antibody (clone 17) | ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0522-LC194 | Mouse Anti-GRIN2B Recombinant Antibody (VS-0522-LC194) | ICC, IP, KO/KD-WB, WB, IF, IHC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0522-LC195 | Rat Anti-GRIN2B Recombinant Antibody (VS-0522-LC195) | ICC, IP, KO/KD-WB, WB, IF, IHC | Rat IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY344 | Mouse Anti-NHP GRIN2B Recombinant Antibody (clone B3-13B11) | WB, IHC, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-FY98 | Human Anti-GRIN2B (clone 2) scFv-Fc Chimera | Inhib | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC700 | Recombinant Anti-Grin2b Vesicular Antibody, EV Displayed (VS-0425-YC700) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2923 | Anti-GRIN2B Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2924 | Anti-Mouse GRIN2B Immunohistochemistry Kit | IHC |
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