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    Mouse Anti-LGALS9 scFv-Fc Chimera (VS-0425-FY37) (CAT#: VS-0425-FY37)

    The anti-LGALS9 scFv-Fc is a specialized therapeutic protein designed to target and neutralize the Galectin-9 (LGALS9) protein, which is involved in various pathological processes, including cancer and autoimmune diseases. This engineered antibody fragment combines the benefits of single-chain variable fragments (scFv) with the Fc domain of IgG, enhancing its stability and effector functions. The product has demonstrated strong binding affinity to LGALS9, making it an effective tool for research and development purposes. Its versatility allows for potential applications in disease modulation and as a therapeutic agent. The anti-LGALS9 scFv-Fc is produced using advanced recombinant DNA technology, ensuring high purity and consistency. Ongoing studies are focusing on its effectiveness in preclinical models.

    Specific Inquiry
    • Size:

    • Conjugation:

    • Endotoxin:

    • Purity:

    • Formats:

    • Isotype Switching:

    • Fc Engineering:

    • Modalities:

    Custom Production

    We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

    Sequences:
    Isotype :
    Purity :
    Endotoxin :
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    Conjugation :
    Fc Engineering :
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    Other Requirements:
    We require custom production
    • Gene Expression
    • Datasheet
    • MSDS
    • COA
    Subcellular Location and Protein Expression
    Figure 1 IF staining of human cell line A-431
    Figure 1 IF staining of human cell line A-431
    (Immunofluorescent staining of human cell line A-431 shows localization to cytosol.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/if_selected.jpg
    Figure 2 IHC staining of human colon
    Figure 2 IHC staining of human colon
    (Immunohistochemical staining of human colon shows cytoplasmic positivity in glandular cells.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/ihc_selected.jpg
    Normal Tissue
    Figure 3 Cerebral cortex
    Figure 3 Cerebral cortex
    (Neuronal cells
    Staining: Medium
    Intensity: Moderate
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous nuclear
    Endothelial cells
    Staining: Low
    Intensity: Weak
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Glial cells
    Staining: Low
    Intensity: Moderate
    Quantity: <25%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/116951_B_9_5.jpg
    Figure 4 Liver
    Figure 4 Liver
    (Hepatocytes
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/116951_A_9_4.jpg
    Figure 5 Kidney
    Figure 5 Kidney
    (Cells in glomeruli
    Staining: Low
    Intensity: Moderate
    Quantity: <25%
    Location: Cytoplasmic/membranous
    Cells in tubules
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/116951_A_8_5.jpg
    Figure 6 Urinary bladder
    Figure 6 Urinary bladder
    (Urothelial cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous nuclear)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/116951_A_4_5.jpg
    Figure 7 Testis
    Figure 7 Testis
    (Cells in seminiferous ducts
    Staining: Low
    Intensity: Weak
    Quantity: 75%-25%
    Location: Cytoplasmic/membranous
    Leydig cells
    Staining: High
    Intensity: Strong
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/116951_A_6_6.jpg
    Figure 8 Lymph node
    Figure 8 Lymph node
    (Germinal center cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous
    Non-germinal center cells
    Staining: Medium
    Intensity: Moderate
    Quantity:>75%
    Location: Cytoplasmic/membranous)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/116951_A_9_8.jpg
    RNA Expression
    Figure 9 RNA cell line category: Cell line enhanced (HL-60, HMC-1, MOLT-4, REH, THP-1, U-937)
    Figure 9 RNA cell line category: Cell line enhanced (HL-60, HMC-1, MOLT-4, REH, THP-1, U-937)
    (Cell lines ordered by descending RNA expression order.)
    * Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000168961-LGALS9

    Specifications

    • Immunogen
    • C-terminal portion of human galectin 9.
    • Host Species
    • Mouse
    • Type
    • Mouse IgG1, scFv-Fc
    • Specificity
    • Human LGALS9
    • Species Reactivity
    • Human
    • Applications
    • Western Blot, ELISA, Inhibition
    • Related Disease
    • Hodgkin's disease

    Product Property

    • Purity
    • >95% as determined by SDS-PAGE
    • Concentration
    • Please refer to the vial label for the specific concentration.
    • Storage
    • Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
    • Shipping
    • Ice packs

    Applications

    • Application Notes
    • Inhibition: 5 μg/mL
      Western Blot: 2ng/μL
      The optimal dilution concentration is determined by the experiment.

    Target

    • Alternative Names
    • LGALS9; Ecalectin; Lectin,Galactoside-Binding Soluble 9; Tumor antigen HOM-HD-21
    • Long Name
    • Galectin 9
    • Cellular Localization
    • Cytoplasm; Nucleus; Secreted
    • Post Translation Modifications
    • Modification sites at PhosphoSitePlus
      Modification sites at neXtProt
    • Function
    • Binds galactosides.
      Has high affinity for the Forssman pentasaccharide.
      Ligand for HAVCR2/TIM3.
      Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death.
      Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth.

    Product Notes

    This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

    • Increased sensitivity
    • Confirmed specificity
    • High repeatability
    • Excellent batch-to-batch consistency
    • Sustainable supply
    • Animal-free production

    See more details about Hi-Affi™ recombinant antibody benefits.

    Downloads

    Download resources about recombinant antibody development and antibody engineering to boost your research.

    See other products for "LGALS9"

    Select a product category from the dropdown menu below to view related products.
    Please select product type
    IgG Antibody Products Mouse Antibody Products Humanized Antibody Products Chimeric Antibody Products Neutralizing Antibody Products Blocking Antibody Products Fab Antibody Products ScFv Antibody Products IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
    CAT Product Name Application Type
    MOB-3377z Mouse Anti-LGALS9 Recombinant Antibody (clone 30D5) WB, IP, IF, ELISA Mouse IgG2b, κ
    FAMAB-0208CQ Mouse Anti-LGALS9 Recombinant Antibody (clone TIB-141) WB, FuncS Mouse IgE
    FN-143CQ Recombinant Rat Anti-LGALS9 Antibody (CBL-1312) FuncS, Block Rat IgG2a, κ
    VS-0723-WK172 Human Anti-LGALS9 Recombinant Antibody (VS-0723-WK172) FC Chimeric (rabbit/human) IgG1
    VS13-YC655 Rabbit Anti-LGALS9 Recombinant Antibody (VS13-YC655) IHC-P Rabbit IgG

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