Mouse Anti-LGALS9 scFv-Fc Chimera (VS-0425-FY37)
CAT#: VS-0425-FY37
The anti-LGALS9 scFv-Fc is a specialized therapeutic protein designed to target and neutralize the Galectin-9 (LGALS9) protein, which is involved in various pathological processes, including cancer and autoimmune diseases. This engineered antibody fragment combines the benefits of single-chain variable fragments (scFv) with the Fc domain of IgG, enhancing its stability and effector functions. The product has demonstrated strong binding affinity to LGALS9, making it an effective tool for research and development purposes. Its versatility allows for potential applications in disease modulation and as a therapeutic agent. The anti-LGALS9 scFv-Fc is produced using advanced recombinant DNA technology, ensuring high purity and consistency. Ongoing studies are focusing on its effectiveness in preclinical models.
Gene Expression
Subcellular Location and Protein Expression
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/if_selected.jpg
Subcellular Location and Protein Expression
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/ihc_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Neuronal cells
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous nuclear
Endothelial cells
Staining: Low
Intensity: Weak
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/116951_B_9_5.jpg
Normal Tissue
Figure 4 Liver
Hepatocytes
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/116951_A_9_4.jpg
Normal Tissue
Figure 5 Kidney
Cells in glomeruli
Staining: Low
Intensity: Moderate
Quantity: <25%
Location: Cytoplasmic/membranous
Cells in tubules
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/116951_A_8_5.jpg
Normal Tissue
Figure 6 Urinary bladder
Urothelial cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/116951_A_4_5.jpg
Normal Tissue
Figure 7 Testis
Cells in seminiferous ducts
Staining: Low
Intensity: Weak
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Leydig cells
Staining: High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/116951_A_6_6.jpg
Normal Tissue
Figure 8 Lymph node
Germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/46876/116951_A_9_8.jpg
RNA Expression
Figure 9 RNA cell line category: Cell line enhanced (HL-60, HMC-1, MOLT-4, REH, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000168961-LGALS9
❮
❯
Specifications
- Immunogen
- C-terminal portion of human galectin 9.
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human LGALS9
- Species Reactivity
- Human
- Applications
- Western Blot, ELISA, Inhibition
- Related Disease
- Hodgkin's disease
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Inhibition: 5 μg/mL
Western Blot: 2ng/μL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- LGALS9; Ecalectin; Lectin,Galactoside-Binding Soluble 9; Tumor antigen HOM-HD-21
- Long Name
- Galectin 9
- Cellular Localization
- Cytoplasm; Nucleus; Secreted
- Post Translation Modifications
- Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- XP_006721955.1; XP_006721956.1; XP_006721958.1; XP_011523098.1; XP_054172020.1
- Function
- Binds galactosides.
Has high affinity for the Forssman pentasaccharide.
Ligand for HAVCR2/TIM3.
Binding to HAVCR2 induces T-helper type 1 lymphocyte (Th1) death.
Also stimulates bactericidal activity in infected macrophages by causing macrophage activation and IL1B secretion which restricts intracellular bacterial growth.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3377z | Mouse Anti-LGALS9 Recombinant Antibody (clone 30D5) | WB, IP, IF, ELISA | Mouse IgG2b, κ |
| FAMAB-0208CQ | Mouse Anti-LGALS9 Recombinant Antibody (clone TIB-141) | WB, FuncS | Mouse IgE |
| FN-143CQ | Recombinant Rat Anti-LGALS9 Antibody (CBL-1312) | FuncS, Block | Rat IgG2a, κ |
| VS-0723-WK172 | Human Anti-LGALS9 Recombinant Antibody (VS-0723-WK172) | FC | Chimeric (rabbit/human) IgG1 |
| VS13-YC655 | Rabbit Anti-LGALS9 Recombinant Antibody (VS13-YC655) | IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-039CQ | Mouse Anti-LGALS9 Recombinant Antibody (TAB-039CQ) | IHC, ELISA, WB | Mouse IgG1, κ |
| TAB-039CQ-S(P) | Mouse Anti-LGALS9 Recombinant Antibody; scFv Fragment (TAB-039CQ-S(P)) | ELISA, FC, WB, Neut | Mouse scFv |
| TAB-042CQ-S(P) | Mouse Anti-LGALS9 Recombinant Antibody; scFv Fragment (TAB-042CQ-S(P)) | ELISA, FC, WB, Neut | Mouse scFv |
| TAB-039CQ-F(E) | Mouse Anti-LGALS9 Recombinant Antibody; Fab Fragment (TAB-039CQ-F(E)) | ELISA, FC, WB, Neut | Mouse Fab |
| TAB-042CQ-F(E) | Mouse Anti-LGALS9 Recombinant Antibody; Fab Fragment (TAB-042CQ-F(E)) | ELISA, FC, WB, Neut | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-040CQ | Human Anti-LGALS9 Recombinant Antibody (TAB-040CQ) | ELISA, FC, WB, Neut | Human IgG1, κ |
| TAB-040CQ-S(P) | Human Anti-LGALS9 Recombinant Antibody; scFv Fragment (TAB-040CQ-S(P)) | ELISA, FC, WB, Neut | Human scFv |
| TAB-043CQ-S(P) | Human Anti-LGALS9 Recombinant Antibody; scFv Fragment (TAB-043CQ-S(P)) | ELISA, FC, WB, Neut | Human scFv |
| TAB-040CQ-F(E) | Human Anti-LGALS9 Recombinant Antibody; Fab Fragment (TAB-040CQ-F(E)) | ELISA, FC, WB, Neut | Humanized Fab |
| TAB-043CQ-F(E) | Human Anti-LGALS9 Recombinant Antibody; Fab Fragment (TAB-043CQ-F(E)) | ELISA, FC, WB, Neut | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-041CQ | Human Anti-LGALS9 Recombinant Antibody (TAB-041CQ) | ELISA, FC, WB, Neut | Chimeric (Mouse/Human) IgG1, κ |
| TAB-041CQ-S(P) | Human Anti-LGALS9 Recombinant Antibody; scFv Fragment (TAB-041CQ-S(P)) | ELISA, FC, WB, Neut | Human scFv |
| TAB-044CQ-S(P) | Human Anti-LGALS9 Recombinant Antibody; scFv Fragment (TAB-044CQ-S(P)) | ELISA, FC, WB, Neut | Human scFv |
| TAB-041CQ-F(E) | Human Anti-LGALS9 Recombinant Antibody; Fab Fragment (TAB-041CQ-F(E)) | ELISA, FC, WB, Neut | Chimeric (Mouse/Human) Fab |
| TAB-044CQ-F(E) | Human Anti-LGALS9 Recombinant Antibody; Fab Fragment (TAB-044CQ-F(E)) | ELISA, FC, WB, Neut | Chimeric (Mouse/Human) Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1688CQ | Recombinant Mouse Anti-LGALS9 Antibody (NEUT-1688CQ) | WB, Neut | IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-1690CQ | Recombinant Rat Anti-Lgals9 Antibody (RG9-1) | BL | IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0208CQ-F(E) | Mouse Anti-LGALS9 Recombinant Antibody (clone TIB-141); Fab Fragment | WB | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0208CQ-S(P) | Mouse Anti-LGALS9 Recombinant Antibody (clone TIB-141); scFv Fragment | WB | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1241 | Anti-LGALS9 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4005 | Anti-Mouse LGALS9 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4006 | Anti-Human LGALS9 Immunohistochemistry Kit | IHC |
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