Mouse Anti-TNFRSF4 (clone 9B12) scFv-Fc Chimera (CAT#: VS-0425-FY77)
This scFv-Fc construct targets TNFRSF4 (OX40), a co-stimulatory receptor on T cells. It is designed for immune checkpoint modulation to enhance T-cell activation and antitumor responses in cancer immunotherapy.
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Normal Tissue
RNA Expression
Figure 1 High expression in lymph node.
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16128/35587_A_7_8.jpg
(Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16128/35587_A_7_8.jpg
Figure 2 Tonsil
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16128/35587_A_6_8.jpg
(Germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/16128/35587_A_6_8.jpg
Figure 3 RNA cell line category: Group enriched (MOLT-4, NB-4)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186827-TNFRSF4
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000186827-TNFRSF4
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG1, scFv-Fc
- Specificity
- Human TNFRSF4
- Species Reactivity
- Human
- Clone
- 9B12
- Applications
- ADCC, Flow Cytometry, ELISA
- Related Disease
- Cancer
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- ADCC: 10 μg/mL
Flow Cytometry: 10 μg/mL
ELISA: 10 μg/mL
The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- TNF Receptor Superfamily Member 4; TAX Transcriptionally-Activated Glycoprotein 1 Receptor; OX40L Receptor; ACT35 Antigen; CD134 Antigen; TXGP1L; Tax-Transcriptionally Activated Glycoprotein 1 Receptor; Tumor Necrosis Factor Receptor Superfamily, Member 4; Tumor Necrosis Factor Receptor Superfamily Member 4; Lymphoid Activation Antigene ACT35
- Gene ID
- 7293
- UniProt ID
- P43489
- Long Name
- TNF Receptor Superfamily Member 4
- Cellular Localization
- Membrane
- Post Translation Modifications
- Glycosylation at Asn146 and Asn160
Glycosylation from GlyGen 3 sites, 1 O-linked glycan (1 site)
- Protein Refseq
- XP_011540376.1; XP_011540378.1; XP_011540379.1; XP_054194578.1; XP_054194579.1
- Function
- Receptor for TNFSF4/OX40L/GP34.
Is a costimulatory molecule implicated in long-term T-cell immunity.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Extracellular Vesicle (EV) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1618z | Mouse Anti-TNFRSF4 Recombinant Antibody (clone 27C4) | WB, ELISA, FC, IHC, IP | Mouse IgG1, κ |
| HPAB-0007-LSX | Human Anti-TNFRSF4 Recombinant Antibody (HPAB-0007-LSX) | ELISA, WB, FC, Block, ADCC, FuncS | Human IgG1 |
| HPAB-0008-LSX | Mouse Anti-TNFRSF4 Recombinant Antibody (HPAB-0008-LSX) | ELISA, WB, FC, Block, ADCC, FuncS | Mouse IgG4 |
| HPAB-0009-LSX | Mouse Anti-TNFRSF4 Recombinant Antibody (HPAB-0009-LSX) | ELISA, WB, FC, Block, ADCC, FuncS | Mouse IgG1 |
| HPAB-0010-LSX | Mouse Anti-TNFRSF4 Recombinant Antibody (clone B66) | ELISA, FC | Mouse IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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