Recombinant Anti-ABCG2 Vesicular Antibody, EV Displayed (VS-0425-YC483)
CAT#: VS-0425-YC483
The Recombinant Anti-ABCG2 Vesicular Antibody, EV Displayed (VS-0425-YC483) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ABCG2-expressed cells or tissues. ABCG2 belongs to the ABC transporter family. The protein facilitates molecule translocation across membranes and contributes to multidrug resistance. This protein is especially noted in the placenta and is alternatively known as the breast cancer resistance protein. Multiple transcript variants exist for ABCG2.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A549
Immunofluorescent staining of human cell line A549 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54719/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/37299/if_selected.jpg
Normal Tissue
Figure 3 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54719/135304_B_7_5.jpg
Normal Tissue
Figure 4 Small intestine
Enterocytes - Microvilli Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54719/135304_A_4_2.jpg
Normal Tissue
Figure 5 Colon
Enterocytes - Microvilli Staining: High Intensity: Strong
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54719/135304_A_9_3.jpg
Normal Tissue
Figure 6 Testis
Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/54719/135304_A_6_6.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (A549, BEWO, MCF7, OE19, RPMI-8226, SuSa)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000118777-ABCG2
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ABCG2
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- ATP binding cassette subfamily G member 2 (Junior blood group)
- Biological Process
- Lipid transport, Transport
- Molecular Function
- Translocase
- Cellular Localization
- Plasma membrane, Nucleoplasm
- Introduction
- The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
- Alternative Names
- ABCP, BCRP, CD338, EST157481, MXR
- Gene ID
- 9429
- UniProt ID
- Q9UNQ0
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Datasheet
MSDS
COA
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See other products for "ABCG2"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0016 | Hi-Affi™ Rabbit Anti-ABCG2 Recombinant Antibody (clone DS16AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-0018-CN | Rabbit Anti-ABCG2 Recombinant Antibody (clone JF0994) | WB, IF, IHC, FC | Rabbit IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0002-YC-S(P) | Mouse Anti-ABCG2 Recombinant Antibody; scFv Fragment (HPAB-M0002-YC-S(P)) | ELISA, WB | Mouse scFv |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0002-YC-F(E) | Mouse Anti-ABCG2 Recombinant Antibody; Fab Fragment (HPAB-M0002-YC-F(E)) | ELISA, WB | Mouse Fab |
| PFBS-0024 | Mouse Anti-ABCG2 Recombinant Antibody (Clone 5D3); Fab Fragment | ELISA, FuncS | Mouse Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS13-YC6 | CytoStream™ Rabbit Anti-ABCG2 Recombinant Antibody (VS13-YC6) | WB, ICC, IF, IHC-P, FC | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY41 | Anti-ABCG2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY42 | Anti-Mouse ABCG2 Immunohistochemistry Kit | IHC |
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