Recombinant Anti-BACE2 Vesicular Antibody, EV Displayed (VS-0425-YC732)
CAT#: VS-0425-YC732
The Recombinant Anti-BACE2 Vesicular Antibody, EV Displayed (VS-0425-YC732) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to BACE2-expressed cells or tissues. BACE2 is an aspartic protease cleaving amyloid precursor protein, implicated in Alzheimer's disease.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Glial cells
Staining: High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
Neuropil
Staining: Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35416/137336_B_7_5.jpg
Normal Tissue
Figure 2 Liver
Hepatocytes
Staining: Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35416/137336_A_9_4.jpg
Normal Tissue
Figure 3 Testis
Leydig cells
Staining: Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35416/137336_A_6_6.jpg
RNA Expression
Figure 4 RNA cell line category: Cell line enhanced (OE19, SK-BR-3, SK-MEL-30, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000182240-BACE2
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- BACE2
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Beta-secretase 2
- Molecular Function
- Aspartyl protease, Hydrolase, Protease
- Introduction
- This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants.
- Alternative Names
- AEPLC, ALP56, CEAP1, DRAP
- Gene ID
- 25825
- UniProt ID
- Q9Y5Z0
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Datasheet
MSDS
COA
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|---|---|---|---|
| MOB-96 | Recombinant Anti-human BACE2 Antibody | WB, IHC, FuncS | IgG |
| MHH-96 | Recombinant Human Anti-human BACE2 Antibody | ELISA, WB, IF, FuncS | IgG |
| PABL-409 | Mouse Anti-BACE2 Recombinant Antibody (clone 19) | ELISA | Mouse IgG |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-96-F(E) | Recombinant Anti-human BACE2 Antibody Fab Fragment | RIA, IF, FuncS | Fab |
| MHH-96-F(E) | Recombinant Human Anti-human BACE2 Antibody Fab Fragment | WB, IF, FuncS | Fab |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-96-S(P) | Recombinant Anti-human BACE2 Antibody scFv Fragment | RIA, ELISA, FuncS | scFv |
| MHH-96-S(P) | Recombinant Human Anti-human BACE2 Antibody scFv Fragment | Neut, IF, FuncS | scFv |
| PSBL-406 | Mouse Anti-BACE2 Recombinant Antibody (clone 19); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-006 | Recombinant Anti-Human BACE2 VHH Single Domain Antibody (PNBL-006) | FACS, ELISA, FuncS | Llama VHH |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-015 | Recombinant Mouse Anti-Bace2 Antibody (Fab1/9) | WB, ELISA, IF, FuncS | IgG |
| PABX-015-F (E) | Recombinant Mouse Anti-Bace2 Antibody Fab Fragment (Fab1/9) | WB, ELISA, IF, FuncS | Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PABX-015-S (P) | Recombinant Mouse Anti-Bace2 Antibody scFv Fragment (Fab1/9) | WB, ELISA, IF, FuncS | scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY678 | Anti-BACE2 Immunohistochemistry Kit | IHC |
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