Recombinant Anti-C5AR1 Vesicular Antibody, EV Displayed (VS-0425-YC251)
CAT#: VS-0425-YC251
The Recombinant Anti-C5AR1 Vesicular Antibody, EV Displayed (VS-0425-YC251) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to C5AR1-expressed cells or tissues. The C5AR1 is a receptor associated with complement and coagulation cascades, linked to lupus and deficiency conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to the Golgi apparatus & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48012/1916_B12_32_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14520/33409_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14520/33409_A_8_3.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14520/33409_B_5_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (A549, CAPAN-2, HMC-1, U-87 MG, U-937)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197405-C5AR1
❮
❯
Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- C5AR1
- Host Animal
- Mouse
- Antibody Isotype
- IgG2a kappa
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Complement C5a receptor 1
- Biological Process
- Chemotaxis
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Cellular Localization
- Golgi apparatus, Vesicles
- Introduction
- C5AR1 (Complement C5a Receptor 1) is a Protein Coding gene. Diseases associated with C5AR1 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus. Among its related pathways are Creation of C4 and C2 activators and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and complement component C5a binding. An important paralog of this gene is C5AR2.
- Alternative Names
- C5A, C5AR, C5R1, CD88
- Gene ID
- 728
- UniProt ID
- P21730
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Datasheet
MSDS
COA
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