Recombinant Anti-C5AR1 Vesicular Antibody, EV Displayed (VS-0425-YC251) (CAT#: VS-0425-YC251)
The Recombinant Anti-C5AR1 Vesicular Antibody, EV Displayed (VS-0425-YC251) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to C5AR1-expressed cells or tissues. The C5AR1 is a receptor associated with complement and coagulation cascades, linked to lupus and deficiency conditions.
Specific Inquiry
Subcellular Location
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HeLa
(Immunofluorescent staining of human cell line HeLa shows localization to the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48012/1916_B12_32_selected.jpg
(Immunofluorescent staining of human cell line HeLa shows localization to the Golgi apparatus & vesicles.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/48012/1916_B12_32_selected.jpg
Figure 2 Cerebral cortex
(Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14520/33409_B_7_5.jpg
(Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14520/33409_B_7_5.jpg
Figure 3 Colon
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14520/33409_A_8_3.jpg
(Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14520/33409_A_8_3.jpg
Figure 4 Bone marrow
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14520/33409_B_5_4.jpg
(Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/14520/33409_B_5_4.jpg
Figure 5 RNA cell line category: Cell line enhanced (A549, CAPAN-2, HMC-1, U-87 MG, U-937)
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197405-C5AR1
(Cell lines ordered by descending RNA expression order)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197405-C5AR1
Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- C5AR1
- Host Animal
- Mouse
- Antibody Isotype
- IgG2a kappa
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Complement C5a receptor 1
- Biological Process
- Chemotaxis
- Molecular Function
- G-protein coupled receptor, Receptor, Transducer
- Cellular Localization
- Golgi apparatus, Vesicles
- Introduction
- C5AR1 (Complement C5a Receptor 1) is a Protein Coding gene. Diseases associated with C5AR1 include Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus. Among its related pathways are Creation of C4 and C2 activators and Complement and coagulation cascades. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and complement component C5a binding. An important paralog of this gene is C5AR2.
- Alternative Names
- C5A, C5AR, C5R1, CD88
- Gene ID
- 728
- UniProt ID
- P21730
Downloads
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ScFv-Fc Chimera Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-1384CL | Human Anti-C5AR1 Recombinant Antibody (TAB-1384CL) | FC, Inhib | Human IgG |
| TAB-1384CL-F(E) | Human Anti-C5AR1 Recombinant Antibody; Fab Fragment (TAB-1384CL-F(E)) | FC, Inhib | Human Fab |
| TAB-1385CL-F(E) | Human Anti-C5AR1 Recombinant Antibody; Fab Fragment (TAB-1385CL-F(E)) | FuncS | Human Fab |
| TAB-1386CL-F(E) | Human Anti-C5AR1 Recombinant Antibody; Fab Fragment (TAB-1386CL-F(E)) | FC, Inhib | Human Fab |
| TAB-1387CL-F(E) | Human Anti-C5AR1 Recombinant Antibody; Fab Fragment (TAB-1387CL-F(E)) | Inhib | Human Fab |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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