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For Research Use Only. Not For Clinical Use.
CD markers, G-protein coupled receptors, Transporters
Intracellular, Membrane (different isoforms)
Group enriched (Macrophages, Kupffer cells, Hofbauer cells, Langerhans cells)
Immune cell enhanced (neutrophil)
Cell line enhanced (A549, CAPAN-2, HMC-1, U-87 MG, U-937)
Homodimer. May also form higher-order oligomers (PubMed:12835319). Interacts (when phosphorylated) with ARRB1 and ARRB2; the interaction is associated with internalization of C5aR (PubMed:12464600). Interacts (via N-terminal domain) with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response (PubMed:15153520, PubMed:15542591, PubMed:21706042).
G-protein coupled receptor, Receptor, Transducer