Human Anti-C5AR1 scFv-Fc Chimera (VS-0425-FY35) (CAT#: VS-0425-FY35)

• Immunogen
• Recombinant human C5AR1 protein.

• Host Species
• Human

• Type
• Human IgG1, scFv-Fc

• Specificity
• Human C5AR1

• Species Reactivity
• Human

• Applications
• ELISA, Flow Cytometry

• Related Disease
• Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus

• Purity
• >95% as determined by SDS-PAGE

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

• Shipping
• Ice packs

• Application Notes
• The optimal dilution concentration is determined by the experiment.

• Alternative Names
• Complement C5a Receptor 1; Complement Component 5a Receptor 1; C5a-R; C5R1; C5AR; Complement Component 5 Receptor 1 (C5a Ligand); C5a Anaphylatoxin Chemotactic Receptor 1; C5a Anaphylatoxin Chemotactic Receptor

• Gene ID
• 728

• UniProt ID
• P21730

• Long Name
• Complement C5a Receptor 1

• Sequence Similarities
• Belongs to the G-protein coupled receptor 1 family.

• Cellular Localization
• Cell membrane; Multi-pass membrane protein; Cytoplasmic vesicle

• Post Translation Modifications
• Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist.
  Sulfation at Tyr-14 is important for CHIPS binding.
  Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to the ligand.
  The key residues involved in this process are Ser-334 and Ser-338.
  Glycosylation at Asn5
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 1 site

• Protein Refseq
• XP_047295256.1; XP_054177881.1; XP_054177882.1; XP_054177883.1; NP_001727.2

• Function
• Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a.
  The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events.
  Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.

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