Human Anti-C5AR1 scFv-Fc Chimera (VS-0425-FY35)
CAT#: VS-0425-FY35
anti-C5AR1 scFv-Fc antibody is a monoclonal antibody that targets C5AR1 with high affinity and specificity. C5AR1 is part of the complement system and is involved in inflammatory responses. The antibody specifically binds to C5AR1 through its single-chain variable fragment (scFv) domain, and the Fc fragment endows it with the ability to interact with immune effector molecules such as Fc receptors and the complement system. This antibody has potential applications in studying the function and mechanism of C5AR1 and may serve as a potential target for treating related diseases.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HeLa
Immunofluorescent staining of human cell line HeLa shows localization to the Golgi apparatus & vesicles.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/48012/1916_B12_32_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14520/33409_B_7_5.jpg
Normal Tissue
Figure 3 Colon
Endothelial cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14520/33409_A_8_3.jpg
Normal Tissue
Figure 4 Bone marrow
Hematopoietic cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/14520/33409_B_5_4.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (A549, CAPAN-2, HMC-1, U-87 MG, U-937)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000197405-C5AR1
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Specifications
- Immunogen
- Recombinant human C5AR1 protein.
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- Human C5AR1
- Species Reactivity
- Human
- Applications
- ELISA, Flow Cytometry
- Related Disease
- Mannose-Binding Lectin Deficiency and Systemic Lupus Erythematosus
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The optimal dilution concentration is determined by the experiment.
Target
- Alternative Names
- Complement C5a Receptor 1; Complement Component 5a Receptor 1; C5a-R; C5R1; C5AR; Complement Component 5 Receptor 1 (C5a Ligand); C5a Anaphylatoxin Chemotactic Receptor 1; C5a Anaphylatoxin Chemotactic Receptor
- Gene ID
- 728
- UniProt ID
- P21730
- Long Name
- Complement C5a Receptor 1
- Sequence Similarities
- Belongs to the G-protein coupled receptor 1 family.
- Cellular Localization
- Cell membrane; Multi-pass membrane protein; Cytoplasmic vesicle
- Post Translation Modifications
- Sulfation plays a critical role in the association of C5aR with C5a, but no significant role in the ability of the receptor to transduce a signal and mobilize calcium in response to a small a small peptide agonist.
Sulfation at Tyr-14 is important for CHIPS binding.
Phosphorylated on serine residues in response to C5a binding, resulting in internalization of the receptor and short-term desensitization to the ligand.
The key residues involved in this process are Ser-334 and Ser-338.
Glycosylation at Asn5
Modification sites at PhosphoSitePlus
Glycosylation from GlyGen 1 site
- Protein Refseq
- XP_047295256.1; XP_054177881.1; XP_054177882.1; XP_054177883.1; NP_001727.2
- Function
- Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a.
The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events.
Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0143-CN-F(E) | Rabbit Anti-C5AR1 Recombinant Antibody; Fab Fragment (HPAB-0143-CN-F(E)) | ELISA, FC | Rabbit Fab |
| HPAB-M0019-YC-F(E) | Mouse Anti-C5AR1 Recombinant Antibody; Fab Fragment (HPAB-M0019-YC-F(E)) | ELISA, FC, Block | Mouse Fab |
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| CAT | Product Name | Application | Type |
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| CAT | Product Name | Application | Type |
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