Recombinant Anti-CCL5 Vesicular Antibody, EV Displayed (VS-0425-YC572) (CAT#: VS-0425-YC572)
The Recombinant Anti-CCL5 Vesicular Antibody, EV Displayed (VS-0425-YC572) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CCL5-expressed cells or tissues. CCL5 (C-C Motif Chemokine Ligand 5) is a protein associated with diseases like ulcer of the lower limbs and periapical granuloma. It plays roles in pathways such as PEDF induced signaling and Toll-like receptor signaling. CCL5 is involved in protein homodimerization and chemokine activity, with an important paralog being CCL3L3.
Specific Inquiry
Normal Tissue
RNA Expression
Figure 1 High expression in bone marrow.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_B_4_4_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_B_4_4_val_selected.jpg
Figure 2 Low expression in skin 1.
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_B_7_1_val_selected.jpg
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_B_7_1_val_selected.jpg
Figure 3 Colon
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_A_8_3.jpg
(Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_A_8_3.jpg
Figure 4 Kidney
(Cells in tubules Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_A_8_5.jpg
(Cells in tubules Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_A_8_5.jpg
Figure 5 RNA cell line category: Cell line enhanced (HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000271503-CCL5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000271503-CCL5
Figure 1 RNA cell line category: Cell line enhanced (HL-60, NB-4, THP-1, U-937)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000271503-CCL5
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000271503-CCL5
Recombinant Antibody
- Application
- ELISA, FC, Inhib, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CCL5
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- C-C motif chemokine ligand 5
- Biological Process
- Chemotaxis, Inflammatory response
- Molecular Function
- Cytokine
- Introduction
- CCL5 (C-C Motif Chemokine Ligand 5) is a Protein Coding gene. Diseases associated with CCL5 include Ulcer Of Lower Limbs and Periapical Granuloma. Among its related pathways are PEDF Induced Signaling and Toll-like receptor signaling pathway. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and chemokine activity. An important paralog of this gene is CCL3L3.
- Alternative Names
- D17S136E, MGC17164, RANTES, SCYA5, SISd, TCP228
- Gene ID
- 6352
- UniProt ID
- P13501
Related Resources
TNF Signaling Pathway
Downloads
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Non-Human Primate (NHP) Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-098CL | Human Anti-CCL5 Recombinant Antibody (TAB-098CL) | ELISA | Human IgG |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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