SmartAb™ Recombinant Anti-CCL5 pH-dependent Antibody (VS-0825-YC33)
CAT#: VS-0825-YC33
The anti-CCL5 pH-dependent antibody (VS-0825-YC33) targets human CCL5 in a pH-dependent manner, with its affinity remaining high at neutral pH but weakening at a lower pH, such as within the acidic environment of endosomes. The anti-CCL5 acid-switched antibody was engineered by incorporating histidine residues into its variable regions. The introduction of histidine substitutions within its Complementarity-Determining Regions (CDRs) enables pH-responsive antigen binding, which leads to enhanced CCL5 clearance. The antibody operates in a cyclical manner, binding CCL5 in the extracellular fluid and releasing it in acidified endosomes. Human CCL5, also known as RANTES, is a chemokine produced by a variety of cells, including T-cells and platelets, that attracts T-cells, eosinophils, and basophils. It plays a significant role in inflammation and has been implicated in the pathogenesis of autoimmune and infectious diseases.
Gene Expression
Normal Tissue
Figure 1 High expression in bone marrow.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_B_4_4_val_selected.jpg
Normal Tissue
Figure 2 Low expression in skin 1.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_B_7_1_val_selected.jpg
Normal Tissue
Figure 3 Colon
Enterocytes - Mucosal lymphoid cells Staining: Medium Intensity: Strong Quantity: <25%
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_A_8_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Not detected Intensity: Weak Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/78447/168177_A_8_5.jpg
RNA Expression
Figure 5 RNA cell line category: Cell line enhanced (HL-60, NB-4, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000271503-CCL5
RNA Expression
Figure 1 RNA cell line category: Cell line enhanced (HL-60, NB-4, THP-1, U-937)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000271503-CCL5
❮
❯
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human CCL5
- Species Reactivity
- Human
- Applications
- ELISA
Product Property
- Clonality
- Monoclonal
- Purification
- Protein A purified
- Purity
- >95%, determined by SDS-PAGE and SEC-HPLC
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- For short-term storage, keep it at 4°C for up to two weeks. For long-term storage, divide the solution into aliquots and freeze them at -20°C or below.
Target
- Alternative Names
- CCL5; chemokine (C-C motif) ligand 5; SISd; eoCP; SCYA5; RANTES; TCP228; D17S136E; SIS-delta; C-C motif chemokine 5; beta-chemokine RANTES; T-cell specific protein p288; eosinophil chemotactic cytokine; small inducible cytokine subfamily A (Cys-Cys), memb
- Gene ID
- 6352
- UniProt ID
- D0EI67
- Long Name
- C-C Motif Chemokine Ligand 5
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Related Signaling Pathways
TNF Signaling Pathway
Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CCL5"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-098CL | Human Anti-CCL5 Recombinant Antibody (TAB-098CL) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0487MZ | Chicken Anti-RANTES Polyclonal IgY | Indirect ELISA, WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-231CQ | Mouse Anti-CCL5 Recombinant Antibody (clone CBL636) | Neut | Mouse IgG2b |
| NEUT-232CQ | Recombinant Mouse Anti-CCL5 Antibody, Unconjugated | ELISA, IHC, Neut | IgG2b |
| NEUT-233CQ | Mouse Anti-CCL5 Recombinant Antibody (clone CBL009) | Neut, WB | Mouse IgG1 |
| NEUT-234CQ | Mouse Anti-CCL5 Recombinant Antibody (clone CBL421) | WB, Neut | Mouse IgG1 |
| NEUT-235CQ | Mouse Anti-CCL5 Recombinant Antibody (clone CBL428) | WB, ELISA(Cap), Neut | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-459CQ | Rat Anti-CCL5 Recombinant Antibody (clone 53405.111) | IF, Inhib | Rat IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-0511 | Hi-Affi™ Rabbit Anti-CCL5 Recombinant Antibody (clone DS511AB) | ICC, WB | Rabbit IgG |
| MOR-4545 | Hi-Affi™ Rabbit Anti-CCL5 Recombinant Antibody (clone TH54DS) | WB, IHC-P | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0378LY | Human Anti-CCL5 Recombinant Antibody (clone 1E4) | ELISA, Inhib | Human IgG1 |
| HPAB-0379LY | Human Anti-CCL5 Recombinant Antibody (clone C8) | ELISA, Inhib | Human IgG1 |
| HPAB-0380LY | Human Anti-CCL5 Recombinant Antibody (clone 1D9) | ELISA, Inhib, FC, IF | Human IgG1 |
| HPAB-0381LY | Human Anti-CCL5 Recombinant Antibody (clone D9) | ELISA, Inhib | Human IgG1 |
| HPAB-0382LY | Human Anti-CCL5 Recombinant Antibody (clone 3E7) | ELISA, Inhib | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0378LY-S(P) | Human Anti-CCL5 Recombinant Antibody (clone 1E4); scfv Fragment | ELISA, Inhib | Human scfv |
| HPAB-0379LY-S(P) | Human Anti-CCL5 Recombinant Antibody (clone C8); scfv Fragment | ELISA, Inhib | Human scfv |
| HPAB-0380LY-S(P) | Human Anti-CCL5 Recombinant Antibody (clone 1D9); scfv Fragment | ELISA, Inhib | Human scfv |
| HPAB-0381LY-S(P) | Human Anti-CCL5 Recombinant Antibody (clone D9); scfv Fragment | ELISA, Inhib | Human scfv |
| HPAB-0382LY-S(P) | Human Anti-CCL5 Recombinant Antibody (clone 3E7); scfv Fragment | ELISA, Inhib | Human scfv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0378LY-F(E) | Human Anti-CCL5 Recombinant Antibody (clone 1E4); Fab Fragment | ELISA, Inhib | Human Fab |
| HPAB-0379LY-F(E) | Human Anti-CCL5 Recombinant Antibody (clone C8); Fab Fragment | ELISA, Inhib | Human Fab |
| HPAB-0380LY-F(E) | Human Anti-CCL5 Recombinant Antibody (clone 1D9); Fab Fragment | ELISA, Inhib | Human Fab |
| HPAB-0381LY-F(E) | Human Anti-CCL5 Recombinant Antibody (clone D9); Fab Fragment | ELISA, Inhib | Human Fab |
| HPAB-0382LY-F(E) | Human Anti-CCL5 Recombinant Antibody (clone 3E7); Fab Fragment | ELISA, Inhib | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY69 | Mouse Anti-NHP CCL5 Recombinant Antibody (VS-1024-XY69) | WB, ELISA | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC572 | Recombinant Anti-CCL5 Vesicular Antibody, EV Displayed (VS-0425-YC572) | ELISA, FC, Inhib, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1069 | Anti-CCL5 Immunohistochemistry Kit | IHC |
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