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CCL5

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Anti-CCL5 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms.
Protein class

Cancer-related genes, Human disease related genes, Plasma proteins

Predicted location

Membrane, Secreted (different isoforms)

Single cell type specificity

Group enriched (NK-cells, dendritic cells, T-cells)

Immune cell specificity

Immune cell enhanced (memory CD8 T-cell, gdT-cell)

Cell line specificity

Cell line enhanced (HL-60, NB-4, THP-1, U-937)

Interaction

Homo and heterooligomers with other chemokines. Interacts with the brown dog tick evasin-4.

Molecular function

Cytokine

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Related Signaling Pathways
TNF Signaling Pathway TNF Signaling Pathway
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