Recombinant Anti-CD226 Vesicular Antibody, EV Displayed (VS-0425-YC693) (CAT#: VS-0425-YC693)
The Recombinant Anti-CD226 Vesicular Antibody, EV Displayed (VS-0425-YC693) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CD226-expressed cells or tissues. CD226 facilitates activities like integrin and protein kinase binding, involved in cytokine production regulation by natural killer cells, with human orthologs expressed in embryos.
Specific Inquiry
Subcellular Location and Protein Expression
Normal Tissue
RNA Expression
Figure 1 IF staining of human cell line HEL
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15865/1847_C10_42_cr5abb48a309a8f_selected.jpg
(Immunofluorescent staining of human cell line HEL shows localization to plasma membrane & centriolar satellites.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15865/1847_C10_42_cr5abb48a309a8f_selected.jpg
Figure 2 IHC staining of human tonsil
(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in cells outside reaction centra.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15715/ihc_selected.jpg
(Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in cells outside reaction centra.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15715/ihc_selected.jpg
Figure 3 Cerebral cortex
(Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15715/37861_B_7_5.jpg
(Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15715/37861_B_7_5.jpg
Figure 4 Lymph node
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15715/37861_A_9_8.jpg
(Germinal center cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
Non-germinal center cells
Staining:High
Intensity: Strong
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/15715/37861_A_9_8.jpg
Figure 5 RNA cell line category: Group enriched (HEL, HMC-1)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000150637-CD226
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000150637-CD226
Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CD226
- Host Animal
- Mouse
- Antibody Isotype
- IgG
- Species Reactivity
- Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- CD226 molecule
- Biological Process
- Cell adhesion
- Molecular Function
- Receptor
- Cellular Localization
- Plasma membrane, Nucleoplasm, Centriolar satellite
- Introduction
- Predicted to enable identical protein binding activity; integrin binding activity; and protein kinase binding activity. Acts upstream of or within positive regulation of natural killer cell cytokine production and positive regulation of type II interferon production. Located in external side of plasma membrane. Is expressed in embryo. Orthologous to human CD226 (CD226 molecule).
- Alternative Names
- DNAM-1, DNAM1, Pta1, TLiSA1
- Gene ID
- 225825
- UniProt ID
- Q8K4F0
Downloads
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Flow Cytometry (FC) related Reagents and Kits: Empowering Cell Function Research
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-316CQ | Mouse Anti-CD226 Recombinant Antibody (clone DX11) | FC, FuncS, IP, Block | Mouse IgG1 |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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