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CD226

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For Research Use Only. Not For Clinical Use.


Background

Predicted to enable identical protein binding activity; integrin binding activity; and protein kinase binding activity. Acts upstream of or within positive regulation of natural killer cell cytokine production and positive regulation of type II interferon production. Located in external side of plasma membrane. Is expressed in embryo. Orthologous to human CD226 (CD226 molecule).
Protein class

CD markers, Human disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (NK-cells, dendritic cells, T-cells, Oligodendrocytes, Macrophages, Microglial cells)

Immune cell specificity

Group enriched (gdT-cell, NK-cell, memory CD4 T-cell, memory CD8 T-cell, naive CD8 T-cell, naive CD4 T-cell, MAIT T-cell, T-reg)

Cell line specificity

Group enriched (HEL, HMC-1)

Interaction

Interacts with PVR and NECTIN2. Competes with PVRIG for NECTIN2-binding.

Molecular function

Receptor

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