Recombinant Anti-CLDN4 Vesicular Antibody, EV Displayed (VS-0425-YC131)
CAT#: VS-0425-YC131
The Recombinant Anti-CLDN4 Vesicular Antibody, EV Displayed (VS-0425-YC131) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to CLDN4-expressed cells or tissues. The CLDN4 is a member of the claudin family, acting as an integral membrane protein and a component of tight junctions. It serves as a receptor for clostridium perfringens enterotoxin (CPE) and is involved in alveolar epithelial barrier function.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_B_7_5.jpg
Normal Tissue
Figure 3 Esophagus
Squamous epithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_B_6_1.jpg
Normal Tissue
Figure 4 High expression in colon.
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_A_8_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A-431, BEWO, CAPAN-2, MCF7, OE19, PC-3, RT4, SK-BR-3)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000189143-CLDN4
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- CLDN4
- Host Animal
- Rat
- Antibody Isotype
- IgG2a
- Species Reactivity
- Mouse
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- Protein A
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- Claudin 4
- Biological Process
- Ion transport, Transport
- Molecular Function
- Chloride channel, Ion channel
- Cellular Localization
- Plasma membrane
- Introduction
- This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a high-affinity receptor for clostridium perfringens enterotoxin (CPE) produced by the bacterium Clostridium perfringens, and the interaction with CPE results in increased membrane permeability by forming small pores in plasma membrane. This protein augments alveolar epithelial barrier function and is induced in acute lung injury. It is highly expressed in pancreatic and ovarian cancers.
- Alternative Names
- Cep-r, Cpetr, Cpetr1
- Gene ID
- 12740
- UniProt ID
- O35054
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "CLDN4"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3288z | Mouse Anti-CLDN4 Recombinant Antibody (clone 38H5) | IHC, IF, WB | Mouse IgG1 |
| ZG-0160J | Mouse Anti-CLDN4 Recombinant Antibody (ZG-0160J) | IHC-P, IF | Mouse IgG |
| ZG-0161J | Mouse Anti-CLDN4 Recombinant Antibody (ZG-0161J) | IHC-P, IF | Mouse IgG |
| ZG-0618J | Rabbit Anti-CLDN4 Recombinant Antibody (clone 2G12) | ELISA | Rabbit IgG |
| VS3-XY3319 | Rabbit Anti-CLDN4 Recombinant Antibody (clone R06-4F2) | WB, IHC-P, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-501LC | Anti-Human CLDN4 Recombinant Antibody (KM3900) | WB, IP, FC | |
| TAB-504LC | Anti-Human CLDN4 Recombinant Antibody (KM3907) | Cyt, FC, WB | |
| TAB-506LC | Anti-Human CLDN4 Recombinant Antibody (TAB-506LC) | FC | |
| TAB-501LC-F(E) | Anti-Human CLDN4 Recombinant Antibody Fab Fragment (KM3900) | WB, IP | |
| TAB-504LC-F(E) | Anti-Human CLDN4 Recombinant Antibody Fab Fragment (KM3907) | WB, IP |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-502LC | Anti-Human CLDN4 Recombinant Antibody (cKM3900) | Cyt, FC, WB | Chimeric antibody (mouse/human) |
| TAB-505LC | Anti-Human CLDN4 Recombinant Antibody (cKM3907) | Cyt, FC, WB | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-503LC | Anti-Human CLDN4 Recombinant Antibody (Humanized KM3900) | Cyt, FC, WB | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1487 | Anti-CLDN4 Immunohistochemistry Kit | IHC |
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