Mouse Anti-CLDN4 Recombinant Antibody (clone ABT-CLD4)
CAT#: VS3-CJ119
This product is a mouse antibody that recognizes CLDN4.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Low Intensity: Weak Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_B_7_5.jpg
Normal Tissue
Figure 3 Esophagus
Squamous epithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_B_6_1.jpg
Normal Tissue
Figure 4 High expression in colon.
Endocrine cells Staining: High Intensity: Strong Enterocytes Staining: High Intensity: Strong Quantity:>75% Enterocytes - Goblet cells Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_A_7_3.jpg
Normal Tissue
Figure 5 Kidney
Collecting ducts Staining: Medium Intensity: Strong Quantity: <25% Distal tubules Staining: High Intensity: Strong Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2610/6439_A_8_5.jpg
RNA Expression
Figure 6 RNA cell line category: Cell line enhanced (A-431, BEWO, CAPAN-2, MCF7, OE19, PC-3, RT4, SK-BR-3)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000189143-CLDN4
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Specifications
- Immunogen
- Synthesized peptide derived from human Claudin 4
- Host Species
- Mouse
- Type
- Mouse IgG2b, κ
- Specificity
- Human CLDN4
- Species Reactivity
- Human
- Clone
- ABT-CLD4
- Applications
- WB, IHC-P
- Conjugate
- Unconjugated
Product Property
- Purification
- Affinity chromatography
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Buffer
- 50% Glycerol, 0.5% BSA, PBS.
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C for short term. Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- This antibody has been tested for use in Western Blot (1:500-1:2000), Immunohistochemistry-Parraffin (1:100-1:500).
Target
- Alternative Names
- CPE-R; CPETR; CPETR1; WBSCR8; hCPE-R; Claudin-4; Clostridium perfringens enterotoxin receptor; CPE-R; CPE-receptor; Williams-Beuren syndrome chromosomal region 8 protein
- Gene ID
- 1364
- UniProt ID
- O14493
- Sequence Similarities
- Belongs to the claudin family.
- Cellular Localization
- Cell junction, Cell membrane
- Post Translation Modifications
- Phosphorylated. Phosphorylation by EPHA2 is stimulated by EFNA1 and alters interaction with TJP1.
- Protein Refseq
- NP_001296.1
- Function
- Channel-forming tight junction protein that mediates paracellular chloride transport in the kidney. Plays a critical role in the paracellular reabsorption of filtered chloride in the kidney collecting ducts. Claudins play a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Recommended Dilution Buffer
- CAT
- Product Name
See other products for "CLDN4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3288z | Mouse Anti-CLDN4 Recombinant Antibody (clone 38H5) | IHC, IF, WB | Mouse IgG1 |
| ZG-0161J | Mouse Anti-CLDN4 Recombinant Antibody (ZG-0161J) | IHC-P, IF | Mouse IgG |
| VS3-CJ120 | Mouse Anti-CLDN4 Recombinant Antibody (clone PT1925) | WB, IHC-P | Mouse IgG2b, κ |
| VS3-CJ121 | Mouse Anti-CLDN4 Recombinant Antibody (VS3-CJ121) | WB, IHC | Mouse IgG2b |
| VS3-XY3319 | Rabbit Anti-CLDN4 Recombinant Antibody (clone R06-4F2) | WB, IHC-P, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-502LC | Anti-Human CLDN4 Recombinant Antibody (cKM3900) | Cyt, FC, WB | Chimeric antibody (mouse/human) |
| TAB-505LC | Anti-Human CLDN4 Recombinant Antibody (cKM3907) | Cyt, FC, WB | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-503LC | Anti-Human CLDN4 Recombinant Antibody (Humanized KM3900) | Cyt, FC, WB | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC131 | Recombinant Anti-CLDN4 Vesicular Antibody, EV Displayed (VS-0425-YC131) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY1487 | Anti-CLDN4 Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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